Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway

BACKGROUND: Mesenchymal stem cells (MSCs) are promising candidates for tissue regeneration and disease treatment. However, long-term in vitro passaging leads to stemness loss of MSCs, resulting in failure of MSC therapy. This study investigated whether the combination of melatonin and human umbilica...

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Detalles Bibliográficos
Autores principales: Aierken, Aili, Li, Balun, Liu, Peng, Cheng, Xuedi, Kou, Zheng, Tan, Ning, Zhang, Mengfei, Yu, Shuai, Shen, Qiaoyan, Du, Xiaomin, Enkhbaatar, Bold Bayar, Zhang, Juqing, Zhang, Rui, Wu, Xiaolong, Wang, Ruibin, He, Xin, Li, Na, Peng, Sha, Jia, Wenwen, Wang, Congrong, Hua, Jinlian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006413/
https://www.ncbi.nlm.nih.gov/pubmed/35414044
http://dx.doi.org/10.1186/s13287-022-02832-0

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