Mind the gap: covariate constrained randomisation can protect against substantial power loss in parallel cluster randomised trials

BACKGROUND: Cluster randomised trials often randomise a small number of units, putting them at risk of poor balance of covariates across treatment arms. Covariate constrained randomisation aims to reduce this risk by removing the worst balanced allocations from consideration. This is known to provid...

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Detalles Bibliográficos
Autores principales: Kristunas, Caroline, Grayling, Michael, Gray, Laura J., Hemming, Karla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006416/
https://www.ncbi.nlm.nih.gov/pubmed/35413793
http://dx.doi.org/10.1186/s12874-022-01588-8

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