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Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells

BACKGROUND: Selectively utilizing alternative mechanisms to repair damaged DNA in essential factors deficient cancer facilitates tumor genetic evolution and contributes to treatment resistance. Synthetic lethality strategies provide a novel scenario to anticancer therapy with DNA repair protein muta...

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Detalles Bibliográficos
Autores principales:	Zhang, Jing, Chen, Mu, Pang, Ying, Cheng, Meng, Huang, Bingsong, Xu, Siyi, Liu, Min, Lian, Hao, Zhong, Chunlong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006432/ https://www.ncbi.nlm.nih.gov/pubmed/35414100 http://dx.doi.org/10.1186/s13046-022-02334-0

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