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Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research
Extracellular vesicles (EVs), spherical biological vesicles, mainly contain nucleic acids, proteins, lipids and metabolites for biological information transfer between cells. Microparticles (MPs), a subtype of EVs, directly emerge from plasma membranes, and have gained interest in recent years. Spec...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006557/ https://www.ncbi.nlm.nih.gov/pubmed/35418077 http://dx.doi.org/10.1186/s12951-022-01358-0 |
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author | Hu, Yan Sun, Yajie Wan, Chao Dai, Xiaomeng Wu, Shuhui Lo, Pui-Chi Huang, Jing Lovell, Jonathan F. Jin, Honglin Yang, Kunyu |
author_facet | Hu, Yan Sun, Yajie Wan, Chao Dai, Xiaomeng Wu, Shuhui Lo, Pui-Chi Huang, Jing Lovell, Jonathan F. Jin, Honglin Yang, Kunyu |
author_sort | Hu, Yan |
collection | PubMed |
description | Extracellular vesicles (EVs), spherical biological vesicles, mainly contain nucleic acids, proteins, lipids and metabolites for biological information transfer between cells. Microparticles (MPs), a subtype of EVs, directly emerge from plasma membranes, and have gained interest in recent years. Specific cell stimulation conditions, such as ultraviolet and X-rays irradiation, can induce the release of MPs, which are endowed with unique antitumor functionalities, either for therapeutic vaccines or as direct antitumor agents. Moreover, the size of MPs (100–1000 nm) and their spherical structures surrounded by a lipid bilayer membrane allow MPs to function as delivery vectors for bioactive antitumor compounds, with favorable phamacokinetic behavior, immunostimulatory activity and biological function, without inherent carrier-specific toxic side effects. In this review, the mechanisms underlying MP biogenesis, factors that influence MP production, properties of MP membranes, size, composition and isolation methods of MPs are discussed. Additionally, the applications and mechanisms of action of MPs, as well as the main hurdles for their applications in cancer management, are introduced. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-9006557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90065572022-04-14 Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research Hu, Yan Sun, Yajie Wan, Chao Dai, Xiaomeng Wu, Shuhui Lo, Pui-Chi Huang, Jing Lovell, Jonathan F. Jin, Honglin Yang, Kunyu J Nanobiotechnology Review Extracellular vesicles (EVs), spherical biological vesicles, mainly contain nucleic acids, proteins, lipids and metabolites for biological information transfer between cells. Microparticles (MPs), a subtype of EVs, directly emerge from plasma membranes, and have gained interest in recent years. Specific cell stimulation conditions, such as ultraviolet and X-rays irradiation, can induce the release of MPs, which are endowed with unique antitumor functionalities, either for therapeutic vaccines or as direct antitumor agents. Moreover, the size of MPs (100–1000 nm) and their spherical structures surrounded by a lipid bilayer membrane allow MPs to function as delivery vectors for bioactive antitumor compounds, with favorable phamacokinetic behavior, immunostimulatory activity and biological function, without inherent carrier-specific toxic side effects. In this review, the mechanisms underlying MP biogenesis, factors that influence MP production, properties of MP membranes, size, composition and isolation methods of MPs are discussed. Additionally, the applications and mechanisms of action of MPs, as well as the main hurdles for their applications in cancer management, are introduced. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-04-13 /pmc/articles/PMC9006557/ /pubmed/35418077 http://dx.doi.org/10.1186/s12951-022-01358-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Hu, Yan Sun, Yajie Wan, Chao Dai, Xiaomeng Wu, Shuhui Lo, Pui-Chi Huang, Jing Lovell, Jonathan F. Jin, Honglin Yang, Kunyu Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research |
title | Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research |
title_full | Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research |
title_fullStr | Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research |
title_full_unstemmed | Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research |
title_short | Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research |
title_sort | microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006557/ https://www.ncbi.nlm.nih.gov/pubmed/35418077 http://dx.doi.org/10.1186/s12951-022-01358-0 |
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