Effect of Recombinant Gonadotropin on Testicular Function and Testicular Sperm Extraction in Five Cases of NR0B1 (DAX1) Pathogenic Variants

BACKGROUND: NR0B1 pathogenic variants can cause congenital adrenal hypoplasia or primary adrenal insufficiency in early childhood usually associated with hypogonadotropic hypogonadism. NR0B1 is necessary for organogenesis of the adrenal cortex and to maintain normal spermatogenesis. In humans, resto...

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Detalles Bibliográficos
Autores principales: Teoli, Jordan, Mezzarobba, Vincent, Renault, Lucie, Mallet, Delphine, Lejeune, Hervé, Chatelain, Pierre, Tixier, Frédérique, Nicolino, Marc, Peretti, Noël, Giscard D’estaing, Sandrine, Cuzin, Béatrice, Dijoud, Frédérique, Roucher-Boulez, Florence, Plotton, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006945/
https://www.ncbi.nlm.nih.gov/pubmed/35432221
http://dx.doi.org/10.3389/fendo.2022.855082

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