Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition

We undertook longitudinal β-amyloid positron emission tomography (Aβ-PET) imaging as a translational tool for monitoring of chronic treatment with the peroxisome proliferator-activated receptor gamma (PPARγ) agonist pioglitazone in Aβ model mice. We thus tested the hypothesis this treatment would re...

Descripción completa

Detalles Bibliográficos
Autores principales: Blume, Tanja, Deussing, Maximilian, Biechele, Gloria, Peters, Finn, Zott, Benedikt, Schmidt, Claudio, Franzmeier, Nicolai, Wind, Karin, Eckenweber, Florian, Sacher, Christian, Shi, Yuan, Ochs, Katharina, Kleinberger, Gernot, Xiang, Xianyuan, Focke, Carola, Lindner, Simon, Gildehaus, Franz-Josef, Beyer, Leonie, von Ungern-Sternberg, Barbara, Bartenstein, Peter, Baumann, Karlheinz, Adelsberger, Helmuth, Rominger, Axel, Cumming, Paul, Willem, Michael, Dorostkar, Mario M., Herms, Jochen, Brendel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007038/
https://www.ncbi.nlm.nih.gov/pubmed/35431893
http://dx.doi.org/10.3389/fnagi.2022.854031

Ejemplares similares

Ejemplares similares