Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer

[Image: see text] Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer and considered a potential target for therapeutic intervention. 4-(Diethylamino)benzaldehyde (DEAB) has been extensively reported as a pan-inhibitor of ALDH isoforms, and here, we rep...

Descripción completa

Detalles Bibliográficos
Autores principales: Ibrahim, Ali I. M., Batlle, Elisabet, Sneha, Smarakan, Jiménez, Rafael, Pequerul, Raquel, Parés, Xavier, Rüngeler, Till, Jha, Vibhu, Tuccinardi, Tiziano, Sadiq, Maria, Frame, Fiona, Maitland, Norman J., Farrés, Jaume, Pors, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007462/
https://www.ncbi.nlm.nih.gov/pubmed/35212533
http://dx.doi.org/10.1021/acs.jmedchem.1c01367

Ejemplares similares

Ejemplares similares