When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer

Trogocytosis modulates immune responses, with still unclear underlying molecular mechanisms. Using leukemia mouse models, we found that lymphocytes perform trogocytosis at high rates with tumor cells. While performing trogocytosis, both Natural Killer (NK) and CD8(+) T cells acquire the checkpoint r...

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Detalles Bibliográficos
Autores principales: Hasim, Mohamed S., Marotel, Marie, Hodgins, Jonathan J., Vulpis, Elisabetta, Makinson, Olivia J., Asif, Sara, Shih, Han-Yun, Scheer, Amit K., MacMillan, Olivia, Alonso, Felipe G., Burke, Kelly P., Cook, David P., Li, Rui, Petrucci, Maria Teresa, Santoni, Angela, Fallon, Padraic G., Sharpe, Arlene H., Sciumè, Giuseppe, Veillette, André, Zingoni, Alessandra, Gray, Douglas A., McCurdy, Arleigh, Ardolino, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007500/
https://www.ncbi.nlm.nih.gov/pubmed/35417234
http://dx.doi.org/10.1126/sciadv.abj3286

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