Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms

Mitochondrial quality control plays an important role in maintaining mitochondrial homeostasis and function. Disruption of mitochondrial quality control degrades brain function. We found that flunarizine (FNZ), a drug whose chronic use causes parkinsonism, led to a parkinsonism-like motor dysfunctio...

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Detalles Bibliográficos
Autores principales: Bao, Feixiang, Zhou, Lingyan, Zhou, Rui, Huang, Qiaoying, Chen, Junguo, Zeng, Sheng, Wu, Yi, Yang, Liang, Qian, Shufang, Wang, Mengfei, He, Xueying, Liang, Shan, Qi, Juntao, Xiang, Ge, Long, Qi, Guo, Jingyi, Ying, Zhongfu, Zhou, Yanshuang, Zhao, Qiuge, Zhang, Jiwei, Zhang, Di, Sun, Wei, Gao, Mi, Wu, Hao, Zhao, Yifan, Nie, Jinfu, Li, Min, Chen, Quan, Chen, Jiekai, Zhang, Xiao, Pan, Guangjin, Zhang, Hong, Li, Mingtao, Tian, Mei, Liu, Xingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007515/
https://www.ncbi.nlm.nih.gov/pubmed/35417232
http://dx.doi.org/10.1126/sciadv.abk2376

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