Cargando…
SANS Study of PPPO in Mixed Solvents and Impact on Polymer Nanoprecipitation
[Image: see text] We investigate the conformation of poly(2,6-diphenyl-p-phenylene oxide) (PPPO) in good and mixed solvents by small-angle neutron scattering (SANS) across its ternary phase diagram. Dichloromethane was selected as a “good” solvent and heptane as a “poor” solvent whose addition event...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007525/ https://www.ncbi.nlm.nih.gov/pubmed/35431332 http://dx.doi.org/10.1021/acs.macromol.1c02030 |
_version_ | 1784686868969816064 |
---|---|
author | O’Connell, Róisín A. Sharratt, William N. Aelmans, Nico J. J. Higgins, Julia S. Cabral, João T. |
author_facet | O’Connell, Róisín A. Sharratt, William N. Aelmans, Nico J. J. Higgins, Julia S. Cabral, João T. |
author_sort | O’Connell, Róisín A. |
collection | PubMed |
description | [Image: see text] We investigate the conformation of poly(2,6-diphenyl-p-phenylene oxide) (PPPO) in good and mixed solvents by small-angle neutron scattering (SANS) across its ternary phase diagram. Dichloromethane was selected as a “good” solvent and heptane as a “poor” solvent whose addition eventually induces demixing and polymer precipitation. Below the overlap concentration c*, the polymer conformation is found to be well described by the polymer-excluded volume model and above by the Ornstein–Zernike expression with a correlation length ξ which depends on the concentration and solvent/nonsolvent ratio. We quantify the decrease in polymer radius of gyration R(g), increase in ξ, and effective χ parameter approaching the phase boundary. Upon flash nanoprecipitation, the characteristic particle radius (estimated by scanning electron microscopy, SEM) is found to scale with polymer concentration as well as with nonsolvent content. Significantly, the solution volume per precipitated particle remains nearly constant at all polymer concentrations. Overall, our findings correlate ternary solution structure with the fabrication of polymer nanoparticles by nonsolvent-induced phase separation and precipitation. |
format | Online Article Text |
id | pubmed-9007525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-90075252022-04-14 SANS Study of PPPO in Mixed Solvents and Impact on Polymer Nanoprecipitation O’Connell, Róisín A. Sharratt, William N. Aelmans, Nico J. J. Higgins, Julia S. Cabral, João T. Macromolecules [Image: see text] We investigate the conformation of poly(2,6-diphenyl-p-phenylene oxide) (PPPO) in good and mixed solvents by small-angle neutron scattering (SANS) across its ternary phase diagram. Dichloromethane was selected as a “good” solvent and heptane as a “poor” solvent whose addition eventually induces demixing and polymer precipitation. Below the overlap concentration c*, the polymer conformation is found to be well described by the polymer-excluded volume model and above by the Ornstein–Zernike expression with a correlation length ξ which depends on the concentration and solvent/nonsolvent ratio. We quantify the decrease in polymer radius of gyration R(g), increase in ξ, and effective χ parameter approaching the phase boundary. Upon flash nanoprecipitation, the characteristic particle radius (estimated by scanning electron microscopy, SEM) is found to scale with polymer concentration as well as with nonsolvent content. Significantly, the solution volume per precipitated particle remains nearly constant at all polymer concentrations. Overall, our findings correlate ternary solution structure with the fabrication of polymer nanoparticles by nonsolvent-induced phase separation and precipitation. American Chemical Society 2022-01-18 2022-02-08 /pmc/articles/PMC9007525/ /pubmed/35431332 http://dx.doi.org/10.1021/acs.macromol.1c02030 Text en © 2022 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | O’Connell, Róisín A. Sharratt, William N. Aelmans, Nico J. J. Higgins, Julia S. Cabral, João T. SANS Study of PPPO in Mixed Solvents and Impact on Polymer Nanoprecipitation |
title | SANS Study of PPPO in Mixed Solvents and Impact on
Polymer Nanoprecipitation |
title_full | SANS Study of PPPO in Mixed Solvents and Impact on
Polymer Nanoprecipitation |
title_fullStr | SANS Study of PPPO in Mixed Solvents and Impact on
Polymer Nanoprecipitation |
title_full_unstemmed | SANS Study of PPPO in Mixed Solvents and Impact on
Polymer Nanoprecipitation |
title_short | SANS Study of PPPO in Mixed Solvents and Impact on
Polymer Nanoprecipitation |
title_sort | sans study of pppo in mixed solvents and impact on
polymer nanoprecipitation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007525/ https://www.ncbi.nlm.nih.gov/pubmed/35431332 http://dx.doi.org/10.1021/acs.macromol.1c02030 |
work_keys_str_mv | AT oconnellroisina sansstudyofpppoinmixedsolventsandimpactonpolymernanoprecipitation AT sharrattwilliamn sansstudyofpppoinmixedsolventsandimpactonpolymernanoprecipitation AT aelmansnicojj sansstudyofpppoinmixedsolventsandimpactonpolymernanoprecipitation AT higginsjulias sansstudyofpppoinmixedsolventsandimpactonpolymernanoprecipitation AT cabraljoaot sansstudyofpppoinmixedsolventsandimpactonpolymernanoprecipitation |