Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

[Image: see text] A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H at...

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Autores principales: McLean, Euan B., Mooney, David T., Burns, David J., Lee, Ai-Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007563/
https://www.ncbi.nlm.nih.gov/pubmed/34995469
http://dx.doi.org/10.1021/acs.orglett.1c04079
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author McLean, Euan B.
Mooney, David T.
Burns, David J.
Lee, Ai-Lan
author_facet McLean, Euan B.
Mooney, David T.
Burns, David J.
Lee, Ai-Lan
author_sort McLean, Euan B.
collection PubMed
description [Image: see text] A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.
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spelling pubmed-90075632022-04-14 Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free McLean, Euan B. Mooney, David T. Burns, David J. Lee, Ai-Lan Org Lett [Image: see text] A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed. American Chemical Society 2022-01-07 2022-01-21 /pmc/articles/PMC9007563/ /pubmed/34995469 http://dx.doi.org/10.1021/acs.orglett.1c04079 Text en © 2022 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle McLean, Euan B.
Mooney, David T.
Burns, David J.
Lee, Ai-Lan
Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free
title Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free
title_full Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free
title_fullStr Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free
title_full_unstemmed Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free
title_short Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free
title_sort direct hydrodecarboxylation of aliphatic carboxylic acids: metal- and light-free
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007563/
https://www.ncbi.nlm.nih.gov/pubmed/34995469
http://dx.doi.org/10.1021/acs.orglett.1c04079
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