Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups

This study provides a whole‐body physiologically‐based pharmacokinetic (PBPK) model of dextromethorphan and its metabolites dextrorphan and dextrorphan O‐glucuronide for predicting the effects of cytochrome P450 2D6 (CYP2D6) drug‐gene interactions (DGIs) on dextromethorphan pharmacokinetics (PK). Mo...

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Detalles Bibliográficos
Autores principales: Rüdesheim, Simeon, Selzer, Dominik, Fuhr, Uwe, Schwab, Matthias, Lehr, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007601/
https://www.ncbi.nlm.nih.gov/pubmed/35257505
http://dx.doi.org/10.1002/psp4.12776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007601/
https://www.ncbi.nlm.nih.gov/pubmed/35257505
http://dx.doi.org/10.1002/psp4.12776

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