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CPAP insufficiency leads to incomplete centrioles that duplicate but fragment

Centrioles are structures that assemble centrosomes. CPAP is critical for centrosome assembly, and its mutations are found in patients with diseases such as primary microcephaly. CPAP’s centrosomal localization, its dynamics, and the consequences of its insufficiency in human cells are poorly unders...

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Detalles Bibliográficos
Autores principales: Vásquez-Limeta, Alejandra, Lukasik, Kimberly, Kong, Dong, Sullenberger, Catherine, Luvsanjav, Delgermaa, Sahabandu, Natalie, Chari, Raj, Loncarek, Jadranka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007748/
https://www.ncbi.nlm.nih.gov/pubmed/35404385
http://dx.doi.org/10.1083/jcb.202108018