Cargando…

The epidemiology of uveal melanoma in Germany: a nationwide report of incidence and survival between 2009 and 2015

PURPOSE: To calculate the overall incidence of uveal melanoma in Germany and to compare incidences in different German states. In addition, we computed the overall and cancer-specific survival rates nationwide. METHODS: Incidence data for the period between 2009 and 2015, covering the entire German...

Descripción completa

Detalles Bibliográficos
Autores principales: Alfaar, Ahmad Samir, Saad, Anas, Wiedemann, Peter, Rehak, Matus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007804/
https://www.ncbi.nlm.nih.gov/pubmed/34605956
http://dx.doi.org/10.1007/s00417-021-05317-7
_version_ 1784686930483478528
author Alfaar, Ahmad Samir
Saad, Anas
Wiedemann, Peter
Rehak, Matus
author_facet Alfaar, Ahmad Samir
Saad, Anas
Wiedemann, Peter
Rehak, Matus
author_sort Alfaar, Ahmad Samir
collection PubMed
description PURPOSE: To calculate the overall incidence of uveal melanoma in Germany and to compare incidences in different German states. In addition, we computed the overall and cancer-specific survival rates nationwide. METHODS: Incidence data for the period between 2009 and 2015, covering the entire German population, was collected through the German Center for Cancer Registry. ICD-O-3 topography codes C69.3-C69.4 and histology codes for melanoma subtypes were used to collect the incidence data. Confidence Intervals with a level of 95% (95% CI) were calculated for rates. Survival was calculated using the Kaplan–Meier. The log-rank test was used for survival comparisons. RESULTS: This study comprised 3654 patients with uveal melanomas, including 467 (12.8%) with iridial and ciliary body tumors. The overall age-standardized incidence rate (ASIR) was 6.41 person per million. Generally, the ASIR was higher in males than females (6.67 (95% CI 6.37–6.98) vs. 6.16 (95% CI 5.88–6.45 per million). Higher crude incidence rates were noted in the northeastern states (12.5 per million (95% CI 10.5–14.7) in Mecklenburg-Vorpommern) compared with the southwestern states (2.1 per million (95% CI 1.7–2.6) in Hessen). The 5-year overall survival stood at 47%, while the cancer-specific survival stood at 84%. Multivariate analysis showed that women, younger patients, and patients living in Berlin achieved significantly higher overall survival. CONCLUSION: Overall ASIR of uveal melanoma in Germany indicates that the disease is more common in males and that it follows the same geographical distribution previously noted in central European countries, with the highest incidence in northern parts of Germany. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00417-021-05317-7.
format Online
Article
Text
id pubmed-9007804
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-90078042022-04-19 The epidemiology of uveal melanoma in Germany: a nationwide report of incidence and survival between 2009 and 2015 Alfaar, Ahmad Samir Saad, Anas Wiedemann, Peter Rehak, Matus Graefes Arch Clin Exp Ophthalmol Oncology PURPOSE: To calculate the overall incidence of uveal melanoma in Germany and to compare incidences in different German states. In addition, we computed the overall and cancer-specific survival rates nationwide. METHODS: Incidence data for the period between 2009 and 2015, covering the entire German population, was collected through the German Center for Cancer Registry. ICD-O-3 topography codes C69.3-C69.4 and histology codes for melanoma subtypes were used to collect the incidence data. Confidence Intervals with a level of 95% (95% CI) were calculated for rates. Survival was calculated using the Kaplan–Meier. The log-rank test was used for survival comparisons. RESULTS: This study comprised 3654 patients with uveal melanomas, including 467 (12.8%) with iridial and ciliary body tumors. The overall age-standardized incidence rate (ASIR) was 6.41 person per million. Generally, the ASIR was higher in males than females (6.67 (95% CI 6.37–6.98) vs. 6.16 (95% CI 5.88–6.45 per million). Higher crude incidence rates were noted in the northeastern states (12.5 per million (95% CI 10.5–14.7) in Mecklenburg-Vorpommern) compared with the southwestern states (2.1 per million (95% CI 1.7–2.6) in Hessen). The 5-year overall survival stood at 47%, while the cancer-specific survival stood at 84%. Multivariate analysis showed that women, younger patients, and patients living in Berlin achieved significantly higher overall survival. CONCLUSION: Overall ASIR of uveal melanoma in Germany indicates that the disease is more common in males and that it follows the same geographical distribution previously noted in central European countries, with the highest incidence in northern parts of Germany. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00417-021-05317-7. Springer Berlin Heidelberg 2021-10-04 2022 /pmc/articles/PMC9007804/ /pubmed/34605956 http://dx.doi.org/10.1007/s00417-021-05317-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Oncology
Alfaar, Ahmad Samir
Saad, Anas
Wiedemann, Peter
Rehak, Matus
The epidemiology of uveal melanoma in Germany: a nationwide report of incidence and survival between 2009 and 2015
title The epidemiology of uveal melanoma in Germany: a nationwide report of incidence and survival between 2009 and 2015
title_full The epidemiology of uveal melanoma in Germany: a nationwide report of incidence and survival between 2009 and 2015
title_fullStr The epidemiology of uveal melanoma in Germany: a nationwide report of incidence and survival between 2009 and 2015
title_full_unstemmed The epidemiology of uveal melanoma in Germany: a nationwide report of incidence and survival between 2009 and 2015
title_short The epidemiology of uveal melanoma in Germany: a nationwide report of incidence and survival between 2009 and 2015
title_sort epidemiology of uveal melanoma in germany: a nationwide report of incidence and survival between 2009 and 2015
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007804/
https://www.ncbi.nlm.nih.gov/pubmed/34605956
http://dx.doi.org/10.1007/s00417-021-05317-7
work_keys_str_mv AT alfaarahmadsamir theepidemiologyofuvealmelanomaingermanyanationwidereportofincidenceandsurvivalbetween2009and2015
AT saadanas theepidemiologyofuvealmelanomaingermanyanationwidereportofincidenceandsurvivalbetween2009and2015
AT wiedemannpeter theepidemiologyofuvealmelanomaingermanyanationwidereportofincidenceandsurvivalbetween2009and2015
AT rehakmatus theepidemiologyofuvealmelanomaingermanyanationwidereportofincidenceandsurvivalbetween2009and2015
AT alfaarahmadsamir epidemiologyofuvealmelanomaingermanyanationwidereportofincidenceandsurvivalbetween2009and2015
AT saadanas epidemiologyofuvealmelanomaingermanyanationwidereportofincidenceandsurvivalbetween2009and2015
AT wiedemannpeter epidemiologyofuvealmelanomaingermanyanationwidereportofincidenceandsurvivalbetween2009and2015
AT rehakmatus epidemiologyofuvealmelanomaingermanyanationwidereportofincidenceandsurvivalbetween2009and2015