The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue

Estrogen promotes breast tissue proliferation and telomerase activation. We investigated the effects of reproductive history on cell cycling and telomere length using a DNA methylation-based estimate of telomere length (DNAmTL) in breast and blood from healthy women donors. We demonstrate that DNAmT...

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Detalles Bibliográficos
Autores principales: Sehl, Mary E., Henry, Jill E., Storniolo, Anna Maria, Horvath, Steve, Ganz, Patricia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007943/
https://www.ncbi.nlm.nih.gov/pubmed/35418123
http://dx.doi.org/10.1038/s41523-022-00410-4
Descripción
Sumario:Estrogen promotes breast tissue proliferation and telomerase activation. We investigated the effects of reproductive history on cell cycling and telomere length using a DNA methylation-based estimate of telomere length (DNAmTL) in breast and blood from healthy women donors. We demonstrate that DNAmTL is shorter in breast than in blood, and that nulliparous women have longer age-adjusted DNAmTL in both breast and blood, potentially explaining their higher risk of breast cancer.

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