The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue

Estrogen promotes breast tissue proliferation and telomerase activation. We investigated the effects of reproductive history on cell cycling and telomere length using a DNA methylation-based estimate of telomere length (DNAmTL) in breast and blood from healthy women donors. We demonstrate that DNAmT...

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Autores principales: Sehl, Mary E., Henry, Jill E., Storniolo, Anna Maria, Horvath, Steve, Ganz, Patricia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007943/
https://www.ncbi.nlm.nih.gov/pubmed/35418123
http://dx.doi.org/10.1038/s41523-022-00410-4
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author Sehl, Mary E.
Henry, Jill E.
Storniolo, Anna Maria
Horvath, Steve
Ganz, Patricia A.
author_facet Sehl, Mary E.
Henry, Jill E.
Storniolo, Anna Maria
Horvath, Steve
Ganz, Patricia A.
author_sort Sehl, Mary E.
collection PubMed
description Estrogen promotes breast tissue proliferation and telomerase activation. We investigated the effects of reproductive history on cell cycling and telomere length using a DNA methylation-based estimate of telomere length (DNAmTL) in breast and blood from healthy women donors. We demonstrate that DNAmTL is shorter in breast than in blood, and that nulliparous women have longer age-adjusted DNAmTL in both breast and blood, potentially explaining their higher risk of breast cancer.
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spelling pubmed-90079432022-04-27 The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue Sehl, Mary E. Henry, Jill E. Storniolo, Anna Maria Horvath, Steve Ganz, Patricia A. NPJ Breast Cancer Brief Communication Estrogen promotes breast tissue proliferation and telomerase activation. We investigated the effects of reproductive history on cell cycling and telomere length using a DNA methylation-based estimate of telomere length (DNAmTL) in breast and blood from healthy women donors. We demonstrate that DNAmTL is shorter in breast than in blood, and that nulliparous women have longer age-adjusted DNAmTL in both breast and blood, potentially explaining their higher risk of breast cancer. Nature Publishing Group UK 2022-04-13 /pmc/articles/PMC9007943/ /pubmed/35418123 http://dx.doi.org/10.1038/s41523-022-00410-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Sehl, Mary E.
Henry, Jill E.
Storniolo, Anna Maria
Horvath, Steve
Ganz, Patricia A.
The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue
title The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue
title_full The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue
title_fullStr The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue
title_full_unstemmed The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue
title_short The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue
title_sort impact of reproductive factors on dna methylation-based telomere length in healthy breast tissue
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007943/
https://www.ncbi.nlm.nih.gov/pubmed/35418123
http://dx.doi.org/10.1038/s41523-022-00410-4
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