Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine

Israel began administering a BNT162b2 booster dose to restore protection following the waning of the 2-dose vaccine. Biological studies have shown that a “fresh” booster dose leads to increased antibody levels compared to a fresh 2-dose vaccine, which may suggest increased effectiveness. To compare...

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Autores principales: Amir, Ofra, Goldberg, Yair, Mandel, Micha, Bar-On, Yinon M., Bodenheimer, Omri, Ash, Nachman, Alroy-Preis, Sharon, Huppert, Amit, Milo, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008037/
https://www.ncbi.nlm.nih.gov/pubmed/35418201
http://dx.doi.org/10.1038/s41467-022-29578-w
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author Amir, Ofra
Goldberg, Yair
Mandel, Micha
Bar-On, Yinon M.
Bodenheimer, Omri
Ash, Nachman
Alroy-Preis, Sharon
Huppert, Amit
Milo, Ron
author_facet Amir, Ofra
Goldberg, Yair
Mandel, Micha
Bar-On, Yinon M.
Bodenheimer, Omri
Ash, Nachman
Alroy-Preis, Sharon
Huppert, Amit
Milo, Ron
author_sort Amir, Ofra
collection PubMed
description Israel began administering a BNT162b2 booster dose to restore protection following the waning of the 2-dose vaccine. Biological studies have shown that a “fresh” booster dose leads to increased antibody levels compared to a fresh 2-dose vaccine, which may suggest increased effectiveness. To compare the real-world effectiveness of a fresh (up to 60 days) booster dose with that of a fresh 2-dose vaccine, we took advantage of a quasi-experimental study that compares populations that were eligible to receive the vaccine at different times due to age-dependent policies. Specifically, we compared the confirmed infection rates in adolescents aged 12–14 (215,653 individuals) who received the 2-dose vaccine and in adolescents aged 16–18 (103,454 individuals) who received the booster dose. Our analysis shows that the confirmed infection rate was lower by a factor of 3.7 (95% CI: 2.7 to 5.2) in the booster group.
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spelling pubmed-90080372022-04-28 Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine Amir, Ofra Goldberg, Yair Mandel, Micha Bar-On, Yinon M. Bodenheimer, Omri Ash, Nachman Alroy-Preis, Sharon Huppert, Amit Milo, Ron Nat Commun Article Israel began administering a BNT162b2 booster dose to restore protection following the waning of the 2-dose vaccine. Biological studies have shown that a “fresh” booster dose leads to increased antibody levels compared to a fresh 2-dose vaccine, which may suggest increased effectiveness. To compare the real-world effectiveness of a fresh (up to 60 days) booster dose with that of a fresh 2-dose vaccine, we took advantage of a quasi-experimental study that compares populations that were eligible to receive the vaccine at different times due to age-dependent policies. Specifically, we compared the confirmed infection rates in adolescents aged 12–14 (215,653 individuals) who received the 2-dose vaccine and in adolescents aged 16–18 (103,454 individuals) who received the booster dose. Our analysis shows that the confirmed infection rate was lower by a factor of 3.7 (95% CI: 2.7 to 5.2) in the booster group. Nature Publishing Group UK 2022-04-13 /pmc/articles/PMC9008037/ /pubmed/35418201 http://dx.doi.org/10.1038/s41467-022-29578-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Amir, Ofra
Goldberg, Yair
Mandel, Micha
Bar-On, Yinon M.
Bodenheimer, Omri
Ash, Nachman
Alroy-Preis, Sharon
Huppert, Amit
Milo, Ron
Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine
title Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine
title_full Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine
title_fullStr Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine
title_full_unstemmed Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine
title_short Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine
title_sort protection following bnt162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008037/
https://www.ncbi.nlm.nih.gov/pubmed/35418201
http://dx.doi.org/10.1038/s41467-022-29578-w
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