Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids

Uterine fibroid (UF) driver mutations in Mediator complex subunit 12 (MED12) trigger genomic instability and tumor development through unknown mechanisms. Herein, we show that MED12 mutations trigger aberrant R-loop-induced replication stress, suggesting a possible route to genomic instability and a...

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Detalles Bibliográficos
Autores principales: Muralimanoharan, Sribalasubashini, Shamby, Ross, Stansbury, Nicholas, Schenken, Robert, de la Pena Avalos, Barbara, Javanmardi, Samin, Dray, Eloise, Sung, Patrick, Boyer, Thomas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008039/
https://www.ncbi.nlm.nih.gov/pubmed/35418189
http://dx.doi.org/10.1038/s41598-022-10188-x

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