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Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro

DNA double-strand break (DSB) is the most severe form of DNA damage and accumulates with age, in which cytoskeletal proteins are polymerized to repair DSB in dividing cells. Since tau is a microtubule-associated protein, we investigate whether DSB is involved in tau pathologies in Alzheimer’s diseas...

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Detalles Bibliográficos
Autores principales:	Asada-Utsugi, Megumi, Uemura, Kengo, Ayaki, Takashi, T. Uemura, Maiko, Minamiyama, Sumio, Hikiami, Ryota, Morimura, Toshifumi, Shodai, Akemi, Ueki, Takatoshi, Takahashi, Ryosuke, Kinoshita, Ayae, Urushitani, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008043/ https://www.ncbi.nlm.nih.gov/pubmed/35418705 http://dx.doi.org/10.1038/s42003-022-03312-0

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