Sulfated alginate oligosaccharide exerts antitumor activity and autophagy induction by inactivating MEK1/ERK/mTOR signaling in a KSR1-dependent manner in osteosarcoma

Alginate oligosaccharide (AOS) has the function to inhibit tumor progression and the sulfated modification can enhance the antitumor activity. To date, the function and mechanism of sulfated AOS (AOS-SO(4)) in tumors remain largely elusive. We prepared AOS by the enzymatic degradation of alginate, c...

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Detalles Bibliográficos
Autores principales: Pan, Zhen, Wei, Xiao-juan, Li, Shi-jie, Guo, Hua, Li, Zhao-hui, Zhang, Ke-ke, Lyu, Qian-qian, Liu, Wei-zhi, Yang, Qing-cheng, Cheng, Dong-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008062/
https://www.ncbi.nlm.nih.gov/pubmed/35418575
http://dx.doi.org/10.1038/s41389-022-00390-x

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