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Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations

It has been suggested to longitudinally monitor Insulin-like growth factor I (IGF-I) as a biomarker for the detection of recombinant growth hormone (GH). Subsequently, it is of interest to understand any confounders of endogenous IGF-I. Herein we have studied if serum IGF-I concentration is affected...

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Autores principales: Lehtihet, Mikael, Stephanou, Christina, Börjesson, Annica, Bhuiyan, Hasanuzzaman, Pohanka, Anton, Ekström, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008280/
https://www.ncbi.nlm.nih.gov/pubmed/35434614
http://dx.doi.org/10.3389/fspor.2022.829940
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author Lehtihet, Mikael
Stephanou, Christina
Börjesson, Annica
Bhuiyan, Hasanuzzaman
Pohanka, Anton
Ekström, Lena
author_facet Lehtihet, Mikael
Stephanou, Christina
Börjesson, Annica
Bhuiyan, Hasanuzzaman
Pohanka, Anton
Ekström, Lena
author_sort Lehtihet, Mikael
collection PubMed
description It has been suggested to longitudinally monitor Insulin-like growth factor I (IGF-I) as a biomarker for the detection of recombinant growth hormone (GH). Subsequently, it is of interest to understand any confounders of endogenous IGF-I. Herein we have studied if serum IGF-I concentration is affected by the intake of anabolic androgenic steroids (AAS) and the potential connection between IGF-I and klotho protein. Moreover, the usefulness of klotho as a biomarker for recombinant GH intake was assessed in healthy male volunteers. An ongoing administration of AAS did not affect the levels of IGF-I. Klotho protein was ~30% higher in men with an ongoing AAS use compared to those with previous (>2 months ago) AAS use, and the serum klotho protein correlated negatively with luteinizing hormone (LH) (r(s) = −0.38, p = 0.04) and follicle stimulating hormone (FSH) (r(s) = −0.35, p = 0.05) levels. Serum IGF-I and klotho concentrations showed no correlation in the AAS using population but showed a strong negative correlation in healthy volunteers (r(s) = −0.86, p = 0.006). The intake of recombinant GH did not affect the serum concentrations of the klotho levels. In conclusion, IGF-I was not affected by supra-physiological AAS doses in men. Interestingly, an association between AAS intake and serum klotho was seen. The usefulness of klotho as an androgen biomarker warrants further studies, whereas klotho can be discarded as a promising biomarker for GH doping.
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spelling pubmed-90082802022-04-15 Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations Lehtihet, Mikael Stephanou, Christina Börjesson, Annica Bhuiyan, Hasanuzzaman Pohanka, Anton Ekström, Lena Front Sports Act Living Sports and Active Living It has been suggested to longitudinally monitor Insulin-like growth factor I (IGF-I) as a biomarker for the detection of recombinant growth hormone (GH). Subsequently, it is of interest to understand any confounders of endogenous IGF-I. Herein we have studied if serum IGF-I concentration is affected by the intake of anabolic androgenic steroids (AAS) and the potential connection between IGF-I and klotho protein. Moreover, the usefulness of klotho as a biomarker for recombinant GH intake was assessed in healthy male volunteers. An ongoing administration of AAS did not affect the levels of IGF-I. Klotho protein was ~30% higher in men with an ongoing AAS use compared to those with previous (>2 months ago) AAS use, and the serum klotho protein correlated negatively with luteinizing hormone (LH) (r(s) = −0.38, p = 0.04) and follicle stimulating hormone (FSH) (r(s) = −0.35, p = 0.05) levels. Serum IGF-I and klotho concentrations showed no correlation in the AAS using population but showed a strong negative correlation in healthy volunteers (r(s) = −0.86, p = 0.006). The intake of recombinant GH did not affect the serum concentrations of the klotho levels. In conclusion, IGF-I was not affected by supra-physiological AAS doses in men. Interestingly, an association between AAS intake and serum klotho was seen. The usefulness of klotho as an androgen biomarker warrants further studies, whereas klotho can be discarded as a promising biomarker for GH doping. Frontiers Media S.A. 2022-03-31 /pmc/articles/PMC9008280/ /pubmed/35434614 http://dx.doi.org/10.3389/fspor.2022.829940 Text en Copyright © 2022 Lehtihet, Stephanou, Börjesson, Bhuiyan, Pohanka and Ekström. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Sports and Active Living
Lehtihet, Mikael
Stephanou, Christina
Börjesson, Annica
Bhuiyan, Hasanuzzaman
Pohanka, Anton
Ekström, Lena
Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations
title Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations
title_full Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations
title_fullStr Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations
title_full_unstemmed Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations
title_short Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations
title_sort studies of igf-i and klotho protein in relation to anabolic-androgenic steroid and growth hormone administrations
topic Sports and Active Living
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008280/
https://www.ncbi.nlm.nih.gov/pubmed/35434614
http://dx.doi.org/10.3389/fspor.2022.829940
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