L-F001, a Multifunctional Fasudil-Lipoic Acid Dimer Prevents RSL3-Induced Ferroptosis via Maintaining Iron Homeostasis and Inhibiting JNK in HT22 Cells

Ferroptosis, an iron-dependent form of non-apoptotic cell death, plays important roles in cerebral ischemia. Previously we have found that L-F001, a novel fasudil-lipoic acid dimer with good pharmacokinetic characters has good neuroprotection against toxin-induced cell death in vitro and in vivo. He...

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Detalles Bibliográficos
Autores principales: Peng, Weijia, Ouyang, Ying, Wang, Shuyi, Hou, Jiawei, Zhu, Zeyu, Yang, Yang, Zhou, Ruiyu, Pi, Rongbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008309/
https://www.ncbi.nlm.nih.gov/pubmed/35431808
http://dx.doi.org/10.3389/fncel.2022.774297

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