Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer

In this review we outline the current evidence for the use of hydrogel rectal spacers in the treatment paradigm for prostate cancer with external beam radiation therapy. We review their development, summarize clinical evidence, risk of adverse events, best practices for placement, treatment planning...

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Autores principales: Repka, Michael C., Creswell, Michael, Lischalk, Jonathan W., Carrasquilla, Michael, Forsthoefel, Matthew, Lee, Jacqueline, Lei, Siyuan, Aghdam, Nima, Kataria, Shaan, Obayomi-Davies, Olusola, Collins, Brian T., Suy, Simeng, Hankins, Ryan A., Collins, Sean P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008358/
https://www.ncbi.nlm.nih.gov/pubmed/35433457
http://dx.doi.org/10.3389/fonc.2022.860848
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author Repka, Michael C.
Creswell, Michael
Lischalk, Jonathan W.
Carrasquilla, Michael
Forsthoefel, Matthew
Lee, Jacqueline
Lei, Siyuan
Aghdam, Nima
Kataria, Shaan
Obayomi-Davies, Olusola
Collins, Brian T.
Suy, Simeng
Hankins, Ryan A.
Collins, Sean P.
author_facet Repka, Michael C.
Creswell, Michael
Lischalk, Jonathan W.
Carrasquilla, Michael
Forsthoefel, Matthew
Lee, Jacqueline
Lei, Siyuan
Aghdam, Nima
Kataria, Shaan
Obayomi-Davies, Olusola
Collins, Brian T.
Suy, Simeng
Hankins, Ryan A.
Collins, Sean P.
author_sort Repka, Michael C.
collection PubMed
description In this review we outline the current evidence for the use of hydrogel rectal spacers in the treatment paradigm for prostate cancer with external beam radiation therapy. We review their development, summarize clinical evidence, risk of adverse events, best practices for placement, treatment planning considerations and finally we outline a framework and rationale for the utilization of rectal spacers when treating unfavorable risk prostate cancer with dose escalated Stereotactic Body Radiation Therapy (SBRT).
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spelling pubmed-90083582022-04-15 Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer Repka, Michael C. Creswell, Michael Lischalk, Jonathan W. Carrasquilla, Michael Forsthoefel, Matthew Lee, Jacqueline Lei, Siyuan Aghdam, Nima Kataria, Shaan Obayomi-Davies, Olusola Collins, Brian T. Suy, Simeng Hankins, Ryan A. Collins, Sean P. Front Oncol Oncology In this review we outline the current evidence for the use of hydrogel rectal spacers in the treatment paradigm for prostate cancer with external beam radiation therapy. We review their development, summarize clinical evidence, risk of adverse events, best practices for placement, treatment planning considerations and finally we outline a framework and rationale for the utilization of rectal spacers when treating unfavorable risk prostate cancer with dose escalated Stereotactic Body Radiation Therapy (SBRT). Frontiers Media S.A. 2022-03-31 /pmc/articles/PMC9008358/ /pubmed/35433457 http://dx.doi.org/10.3389/fonc.2022.860848 Text en Copyright © 2022 Repka, Creswell, Lischalk, Carrasquilla, Forsthoefel, Lee, Lei, Aghdam, Kataria, Obayomi-Davies, Collins, Suy, Hankins and Collins https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Repka, Michael C.
Creswell, Michael
Lischalk, Jonathan W.
Carrasquilla, Michael
Forsthoefel, Matthew
Lee, Jacqueline
Lei, Siyuan
Aghdam, Nima
Kataria, Shaan
Obayomi-Davies, Olusola
Collins, Brian T.
Suy, Simeng
Hankins, Ryan A.
Collins, Sean P.
Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer
title Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer
title_full Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer
title_fullStr Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer
title_full_unstemmed Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer
title_short Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer
title_sort rationale for utilization of hydrogel rectal spacers in dose escalated sbrt for the treatment of unfavorable risk prostate cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008358/
https://www.ncbi.nlm.nih.gov/pubmed/35433457
http://dx.doi.org/10.3389/fonc.2022.860848
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