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Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth (Adv. Sci. 11/2022)
Identification of a STIM1 Splicing Variant In article number 2103940, Guolin Ma, Youjun Wang, Yubin Zhou, Weidong Han, and co‐workers report STIM1β – an endoplasmic reticulum (ER)‐resident protein situating at the ER‐plasma membrane junction – as a novel splicing variant that is aberrantly upregulat...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008409/ http://dx.doi.org/10.1002/advs.202270072 |
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author | Xie, Jiansheng Ma, Guolin Zhou, Lijuan He, Lian Zhang, Zhao Tan, Peng Huang, Zixian Fang, Shaohai Wang, Tianlu Lee, Yi‐Tsang Wen, Shufan Siwko, Stefan Wang, Liuqing Liu, Jindou Du, Yangchun Zhang, Ningxia Liu, Xiaoxuan Han, Leng Huang, Yun Wang, Rui Wang, Youjun Zhou, Yubin Han, Weidong |
author_facet | Xie, Jiansheng Ma, Guolin Zhou, Lijuan He, Lian Zhang, Zhao Tan, Peng Huang, Zixian Fang, Shaohai Wang, Tianlu Lee, Yi‐Tsang Wen, Shufan Siwko, Stefan Wang, Liuqing Liu, Jindou Du, Yangchun Zhang, Ningxia Liu, Xiaoxuan Han, Leng Huang, Yun Wang, Rui Wang, Youjun Zhou, Yubin Han, Weidong |
author_sort | Xie, Jiansheng |
collection | PubMed |
description | Identification of a STIM1 Splicing Variant In article number 2103940, Guolin Ma, Youjun Wang, Yubin Zhou, Weidong Han, and co‐workers report STIM1β – an endoplasmic reticulum (ER)‐resident protein situating at the ER‐plasma membrane junction – as a novel splicing variant that is aberrantly upregulated in glioblastoma cells but remains low in immune cells. STIM1β contains a 31‐residue extra polypeptide (red switch) that sabotages the intramolecular inhibition machinery to elicit influx of calcium ions (meteor shower), glioma cell growth and migration (analogous to the recent Tonga volcano eruption). Compared to pan‐STIM inhibition that tends to cause undesired immunosuppressive effects, targeting STIM1β might offer a solution for more precise glioblastoma intervention. [Image: see text] |
format | Online Article Text |
id | pubmed-9008409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90084092022-04-15 Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth (Adv. Sci. 11/2022) Xie, Jiansheng Ma, Guolin Zhou, Lijuan He, Lian Zhang, Zhao Tan, Peng Huang, Zixian Fang, Shaohai Wang, Tianlu Lee, Yi‐Tsang Wen, Shufan Siwko, Stefan Wang, Liuqing Liu, Jindou Du, Yangchun Zhang, Ningxia Liu, Xiaoxuan Han, Leng Huang, Yun Wang, Rui Wang, Youjun Zhou, Yubin Han, Weidong Adv Sci (Weinh) Back Cover Identification of a STIM1 Splicing Variant In article number 2103940, Guolin Ma, Youjun Wang, Yubin Zhou, Weidong Han, and co‐workers report STIM1β – an endoplasmic reticulum (ER)‐resident protein situating at the ER‐plasma membrane junction – as a novel splicing variant that is aberrantly upregulated in glioblastoma cells but remains low in immune cells. STIM1β contains a 31‐residue extra polypeptide (red switch) that sabotages the intramolecular inhibition machinery to elicit influx of calcium ions (meteor shower), glioma cell growth and migration (analogous to the recent Tonga volcano eruption). Compared to pan‐STIM inhibition that tends to cause undesired immunosuppressive effects, targeting STIM1β might offer a solution for more precise glioblastoma intervention. [Image: see text] John Wiley and Sons Inc. 2022-04-14 /pmc/articles/PMC9008409/ http://dx.doi.org/10.1002/advs.202270072 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Back Cover Xie, Jiansheng Ma, Guolin Zhou, Lijuan He, Lian Zhang, Zhao Tan, Peng Huang, Zixian Fang, Shaohai Wang, Tianlu Lee, Yi‐Tsang Wen, Shufan Siwko, Stefan Wang, Liuqing Liu, Jindou Du, Yangchun Zhang, Ningxia Liu, Xiaoxuan Han, Leng Huang, Yun Wang, Rui Wang, Youjun Zhou, Yubin Han, Weidong Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth (Adv. Sci. 11/2022) |
title | Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth (Adv. Sci. 11/2022) |
title_full | Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth (Adv. Sci. 11/2022) |
title_fullStr | Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth (Adv. Sci. 11/2022) |
title_full_unstemmed | Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth (Adv. Sci. 11/2022) |
title_short | Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth (Adv. Sci. 11/2022) |
title_sort | identification of a stim1 splicing variant that promotes glioblastoma growth (adv. sci. 11/2022) |
topic | Back Cover |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008409/ http://dx.doi.org/10.1002/advs.202270072 |
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