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Two Case Reports of Subacute Thyroiditis after Receiving Vaccine for COVID-19

The ongoing COVID-19 pandemic, caused by a coronavirus named SARS-CoV-2, has struck the planet with great force. As of December 2019, the virus has made its devasting route across all continents . In January 2022, the World Health Organization (WHO) registered over 5.5 million COVID-19 related death...

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Autores principales: Adelmeyer, Jan, Goebel, Joachim Nils, Kauka, Alexander, Kann, Peter Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008488/
https://www.ncbi.nlm.nih.gov/pubmed/35433060
http://dx.doi.org/10.1155/2022/3180004
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author Adelmeyer, Jan
Goebel, Joachim Nils
Kauka, Alexander
Kann, Peter Herbert
author_facet Adelmeyer, Jan
Goebel, Joachim Nils
Kauka, Alexander
Kann, Peter Herbert
author_sort Adelmeyer, Jan
collection PubMed
description The ongoing COVID-19 pandemic, caused by a coronavirus named SARS-CoV-2, has struck the planet with great force. As of December 2019, the virus has made its devasting route across all continents . In January 2022, the World Health Organization (WHO) registered over 5.5 million COVID-19 related deaths. Most of these people had suffered from pneumonia and acute respiratory distress syndrome , and in some cases, extensive damage to all organ systems. To get hold of this pandemic, it was vital to find effective vaccines against it. The two vaccine candidates BNT162b2 (BioNTech/Pfizer) and ChAdOx1 (University of Oxford and AstraZeneca) offer a high level of protection against COVID-19 by providing immunity due to antibody production against the spike protein of SARS-CoV-2. In addition to general side effects, immunological side effects such as subacute thyroiditis can follow the vaccination. This transient inflammatory condition of the thyroid gland is characterized with hyperthyroxinemia, inflammation, pain, and tenderness in the thyroid region, as well as an elevation of serum thyroglobulin concentration. There are only a few reports on the occurrence of this disease after receiving a COVID-19 vaccine. We present two cases of subacute thyroiditis after vaccination with the vaccines BNT162b2 and ChAdOx1 and try to enlighten the problem of immunological phenomena after vaccination. It must be discussed whether cross-reactivity of the spike protein and tissue proteins such as thyroid peroxidase (TPO), an “autoimmune/inflammatory syndrome by adjuvants” (ASIA), or the circulating spike protein itself after vaccination are responsible for the SAT.
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spelling pubmed-90084882022-04-15 Two Case Reports of Subacute Thyroiditis after Receiving Vaccine for COVID-19 Adelmeyer, Jan Goebel, Joachim Nils Kauka, Alexander Kann, Peter Herbert Case Rep Endocrinol Case Report The ongoing COVID-19 pandemic, caused by a coronavirus named SARS-CoV-2, has struck the planet with great force. As of December 2019, the virus has made its devasting route across all continents . In January 2022, the World Health Organization (WHO) registered over 5.5 million COVID-19 related deaths. Most of these people had suffered from pneumonia and acute respiratory distress syndrome , and in some cases, extensive damage to all organ systems. To get hold of this pandemic, it was vital to find effective vaccines against it. The two vaccine candidates BNT162b2 (BioNTech/Pfizer) and ChAdOx1 (University of Oxford and AstraZeneca) offer a high level of protection against COVID-19 by providing immunity due to antibody production against the spike protein of SARS-CoV-2. In addition to general side effects, immunological side effects such as subacute thyroiditis can follow the vaccination. This transient inflammatory condition of the thyroid gland is characterized with hyperthyroxinemia, inflammation, pain, and tenderness in the thyroid region, as well as an elevation of serum thyroglobulin concentration. There are only a few reports on the occurrence of this disease after receiving a COVID-19 vaccine. We present two cases of subacute thyroiditis after vaccination with the vaccines BNT162b2 and ChAdOx1 and try to enlighten the problem of immunological phenomena after vaccination. It must be discussed whether cross-reactivity of the spike protein and tissue proteins such as thyroid peroxidase (TPO), an “autoimmune/inflammatory syndrome by adjuvants” (ASIA), or the circulating spike protein itself after vaccination are responsible for the SAT. Hindawi 2022-04-14 /pmc/articles/PMC9008488/ /pubmed/35433060 http://dx.doi.org/10.1155/2022/3180004 Text en Copyright © 2022 Jan Adelmeyer et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Adelmeyer, Jan
Goebel, Joachim Nils
Kauka, Alexander
Kann, Peter Herbert
Two Case Reports of Subacute Thyroiditis after Receiving Vaccine for COVID-19
title Two Case Reports of Subacute Thyroiditis after Receiving Vaccine for COVID-19
title_full Two Case Reports of Subacute Thyroiditis after Receiving Vaccine for COVID-19
title_fullStr Two Case Reports of Subacute Thyroiditis after Receiving Vaccine for COVID-19
title_full_unstemmed Two Case Reports of Subacute Thyroiditis after Receiving Vaccine for COVID-19
title_short Two Case Reports of Subacute Thyroiditis after Receiving Vaccine for COVID-19
title_sort two case reports of subacute thyroiditis after receiving vaccine for covid-19
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008488/
https://www.ncbi.nlm.nih.gov/pubmed/35433060
http://dx.doi.org/10.1155/2022/3180004
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