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Rapidly Progressive Classic Adamantinoma of the Spine: Case Report and Literature Review

Adamantinoma is a locally aggressive or malignant tumor, accounting for <0.5% of all primary bone tumors. The tumor usually progresses slowly, with a relatively promising prognosis. Primary or metastatic spinal adamantinoma of bone are rarer. Only four cases have been documented till date. We pre...

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Autores principales: Lou, Yan, Li, Ying, Xu, Lei, Jing, Xiaoping, Chen, Su, Yang, Minglei, Jiang, Hongyu, Zhao, Chenglong, Wei, Haifeng, Xiao, Jianru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008729/
https://www.ncbi.nlm.nih.gov/pubmed/35433416
http://dx.doi.org/10.3389/fonc.2022.862243
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author Lou, Yan
Li, Ying
Xu, Lei
Jing, Xiaoping
Chen, Su
Yang, Minglei
Jiang, Hongyu
Zhao, Chenglong
Wei, Haifeng
Xiao, Jianru
author_facet Lou, Yan
Li, Ying
Xu, Lei
Jing, Xiaoping
Chen, Su
Yang, Minglei
Jiang, Hongyu
Zhao, Chenglong
Wei, Haifeng
Xiao, Jianru
author_sort Lou, Yan
collection PubMed
description Adamantinoma is a locally aggressive or malignant tumor, accounting for <0.5% of all primary bone tumors. The tumor usually progresses slowly, with a relatively promising prognosis. Primary or metastatic spinal adamantinoma of bone are rarer. Only four cases have been documented till date. We present two cases of aggressive spinal adamantinoma whose microphotography and radiographic appearance were unusual, with extensive involvement of multiple segments and rapid progression. Case 1 was a 36-year-old woman, presenting with back pain, progressive numbness and motor weakness, who was diagnosed with metastatic adamantinoma in the T2, T7, L2, and L4. She underwent spondylectomy three times to resect these lesions, respectively. Case 2 was a 68-year-old male with complaints of severe left back pain. MRI revealed destructive changes in T1-T4. He underwent posterior decompression (T1-T3), partial vertebrectomy (T2), fixation and fusion (C5-C7, T4-T6). The pathology of two patients was metastatic spinal adamantinoma, whose primary lesions were from tibia and femoral adamantinoma, respectively. Rapid squamous progression was observed in specimens of T2 and T7 lesions of Case 1 in two months. Twenty-five months after surgery, Case 1 developed paralysis, but she refused to receive further examination and treatment. Two months after surgery, Case 2 presented with an upper back pain again. The MRI revealed an increase in osseous destruction and paravertebral mass size. He was administered radiotherapy, with his upper back pain partially relieved. The biological behavior of classic adamantinoma is highly unpredictable, often exhibiting more aggressive behavior upon recurrence or metastasis. The pathological diagnosis of adamantinoma should be confirmed by preoperative biopsy. En bloc resection with a wide margin is the preferred treatment for primary spinal adamantinoma. Radiation therapy can partially relieve the pain.
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spelling pubmed-90087292022-04-15 Rapidly Progressive Classic Adamantinoma of the Spine: Case Report and Literature Review Lou, Yan Li, Ying Xu, Lei Jing, Xiaoping Chen, Su Yang, Minglei Jiang, Hongyu Zhao, Chenglong Wei, Haifeng Xiao, Jianru Front Oncol Oncology Adamantinoma is a locally aggressive or malignant tumor, accounting for <0.5% of all primary bone tumors. The tumor usually progresses slowly, with a relatively promising prognosis. Primary or metastatic spinal adamantinoma of bone are rarer. Only four cases have been documented till date. We present two cases of aggressive spinal adamantinoma whose microphotography and radiographic appearance were unusual, with extensive involvement of multiple segments and rapid progression. Case 1 was a 36-year-old woman, presenting with back pain, progressive numbness and motor weakness, who was diagnosed with metastatic adamantinoma in the T2, T7, L2, and L4. She underwent spondylectomy three times to resect these lesions, respectively. Case 2 was a 68-year-old male with complaints of severe left back pain. MRI revealed destructive changes in T1-T4. He underwent posterior decompression (T1-T3), partial vertebrectomy (T2), fixation and fusion (C5-C7, T4-T6). The pathology of two patients was metastatic spinal adamantinoma, whose primary lesions were from tibia and femoral adamantinoma, respectively. Rapid squamous progression was observed in specimens of T2 and T7 lesions of Case 1 in two months. Twenty-five months after surgery, Case 1 developed paralysis, but she refused to receive further examination and treatment. Two months after surgery, Case 2 presented with an upper back pain again. The MRI revealed an increase in osseous destruction and paravertebral mass size. He was administered radiotherapy, with his upper back pain partially relieved. The biological behavior of classic adamantinoma is highly unpredictable, often exhibiting more aggressive behavior upon recurrence or metastasis. The pathological diagnosis of adamantinoma should be confirmed by preoperative biopsy. En bloc resection with a wide margin is the preferred treatment for primary spinal adamantinoma. Radiation therapy can partially relieve the pain. Frontiers Media S.A. 2022-03-31 /pmc/articles/PMC9008729/ /pubmed/35433416 http://dx.doi.org/10.3389/fonc.2022.862243 Text en Copyright © 2022 Lou, Li, Xu, Jing, Chen, Yang, Jiang, Zhao, Wei and Xiao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lou, Yan
Li, Ying
Xu, Lei
Jing, Xiaoping
Chen, Su
Yang, Minglei
Jiang, Hongyu
Zhao, Chenglong
Wei, Haifeng
Xiao, Jianru
Rapidly Progressive Classic Adamantinoma of the Spine: Case Report and Literature Review
title Rapidly Progressive Classic Adamantinoma of the Spine: Case Report and Literature Review
title_full Rapidly Progressive Classic Adamantinoma of the Spine: Case Report and Literature Review
title_fullStr Rapidly Progressive Classic Adamantinoma of the Spine: Case Report and Literature Review
title_full_unstemmed Rapidly Progressive Classic Adamantinoma of the Spine: Case Report and Literature Review
title_short Rapidly Progressive Classic Adamantinoma of the Spine: Case Report and Literature Review
title_sort rapidly progressive classic adamantinoma of the spine: case report and literature review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008729/
https://www.ncbi.nlm.nih.gov/pubmed/35433416
http://dx.doi.org/10.3389/fonc.2022.862243
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