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A Series of Photosensitizes for Fe(3+) in Aqueous Solution and Cells With Colorimetric and Fluorescent Channels: Synthesis and Performance

Ferrum (Fe) is a widely existing metal element and nearly the most important trace element in living species, including human beings. The design of chemosensors for Fe ions faces issues related to the d-d transition of Fe(II) and Fe(III) ions, which makes them efficient electron trappers and energy...

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Autores principales: Xu, Ming, Liao, Jiang-Tao, Chen, Gang, Chen, Yin-Yun, Liu, Dan, Wang, Li-Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008735/
https://www.ncbi.nlm.nih.gov/pubmed/35433632
http://dx.doi.org/10.3389/fchem.2022.867808
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author Xu, Ming
Liao, Jiang-Tao
Chen, Gang
Chen, Yin-Yun
Liu, Dan
Wang, Li-Le
author_facet Xu, Ming
Liao, Jiang-Tao
Chen, Gang
Chen, Yin-Yun
Liu, Dan
Wang, Li-Le
author_sort Xu, Ming
collection PubMed
description Ferrum (Fe) is a widely existing metal element and nearly the most important trace element in living species, including human beings. The design of chemosensors for Fe ions faces issues related to the d-d transition of Fe(II) and Fe(III) ions, which makes them efficient electron trappers and energy quenchers. Most fluorescent dyes cannot afford such d-d quenching, showing emission turn off effect towards both Fe(II) and Fe(III) ions with poor selectivity. As a consequence, the development for Fe with emission turn on effect and good selectivity shall be continued and updated. In this work, three rhodamine-derived chemosensors modified by different lengths of alkyl chains having electron-donating N and O atoms were synthesized and explored for the selective optical sensing of Fe(III). These chemosensors showed colorimetric and fluorescent emission turn on sensing for Fe(III), showing two sensing channels. These chemosensors showed good selectivity, which was assigned to the sieving effect of alkyl chains with electron-donating N and O atoms. The N atom was found to be more effective in associating with Fe(III), compared to the O atom. Their fluorescent cell imaging experiment was carried out to confirm the possibility of being used for cell imaging.
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spelling pubmed-90087352022-04-15 A Series of Photosensitizes for Fe(3+) in Aqueous Solution and Cells With Colorimetric and Fluorescent Channels: Synthesis and Performance Xu, Ming Liao, Jiang-Tao Chen, Gang Chen, Yin-Yun Liu, Dan Wang, Li-Le Front Chem Chemistry Ferrum (Fe) is a widely existing metal element and nearly the most important trace element in living species, including human beings. The design of chemosensors for Fe ions faces issues related to the d-d transition of Fe(II) and Fe(III) ions, which makes them efficient electron trappers and energy quenchers. Most fluorescent dyes cannot afford such d-d quenching, showing emission turn off effect towards both Fe(II) and Fe(III) ions with poor selectivity. As a consequence, the development for Fe with emission turn on effect and good selectivity shall be continued and updated. In this work, three rhodamine-derived chemosensors modified by different lengths of alkyl chains having electron-donating N and O atoms were synthesized and explored for the selective optical sensing of Fe(III). These chemosensors showed colorimetric and fluorescent emission turn on sensing for Fe(III), showing two sensing channels. These chemosensors showed good selectivity, which was assigned to the sieving effect of alkyl chains with electron-donating N and O atoms. The N atom was found to be more effective in associating with Fe(III), compared to the O atom. Their fluorescent cell imaging experiment was carried out to confirm the possibility of being used for cell imaging. Frontiers Media S.A. 2022-03-31 /pmc/articles/PMC9008735/ /pubmed/35433632 http://dx.doi.org/10.3389/fchem.2022.867808 Text en Copyright © 2022 Xu, Liao, Chen, Chen, Liu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Xu, Ming
Liao, Jiang-Tao
Chen, Gang
Chen, Yin-Yun
Liu, Dan
Wang, Li-Le
A Series of Photosensitizes for Fe(3+) in Aqueous Solution and Cells With Colorimetric and Fluorescent Channels: Synthesis and Performance
title A Series of Photosensitizes for Fe(3+) in Aqueous Solution and Cells With Colorimetric and Fluorescent Channels: Synthesis and Performance
title_full A Series of Photosensitizes for Fe(3+) in Aqueous Solution and Cells With Colorimetric and Fluorescent Channels: Synthesis and Performance
title_fullStr A Series of Photosensitizes for Fe(3+) in Aqueous Solution and Cells With Colorimetric and Fluorescent Channels: Synthesis and Performance
title_full_unstemmed A Series of Photosensitizes for Fe(3+) in Aqueous Solution and Cells With Colorimetric and Fluorescent Channels: Synthesis and Performance
title_short A Series of Photosensitizes for Fe(3+) in Aqueous Solution and Cells With Colorimetric and Fluorescent Channels: Synthesis and Performance
title_sort series of photosensitizes for fe(3+) in aqueous solution and cells with colorimetric and fluorescent channels: synthesis and performance
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008735/
https://www.ncbi.nlm.nih.gov/pubmed/35433632
http://dx.doi.org/10.3389/fchem.2022.867808
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