Polyethylene Glycol‐Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart

Protein therapeutics, except for antibodies, have a short plasma half‐life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. However, unlike previously thought, PEG is immunogenic. In addition to induced PEG antibodies, ≈70%...

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Detalles Bibliográficos
Autores principales: Ozer, Imran, Kelly, Garrett, Gu, Renpeng, Li, Xinghai, Zakharov, Nikita, Sirohi, Parul, Nair, Smita K., Collier, Joel H., Hershfield, Michael S., Hucknall, Angus M., Chilkoti, Ashutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008788/
https://www.ncbi.nlm.nih.gov/pubmed/35133079
http://dx.doi.org/10.1002/advs.202103672

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