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Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases

Fucoidan is a marine polysaccharide. In recent years, fucoidan has attracted wide-scale attention from the pharmaceutical industries due to its diverse biological activities such as lipid-lowering, anti-atherosclerosis, and anticoagulation. This review clarifies the pharmacological effects of fucoid...

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Detalles Bibliográficos
Autores principales: Wang, Ke, Xu, Xueli, Wei, Qiang, Yang, Qiong, Zhao, Jiarui, Wang, Yuan, Li, Xia, Ji, Kai, Song, Shuliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008857/
https://www.ncbi.nlm.nih.gov/pubmed/35432845
http://dx.doi.org/10.1177/20406223221076891
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author Wang, Ke
Xu, Xueli
Wei, Qiang
Yang, Qiong
Zhao, Jiarui
Wang, Yuan
Li, Xia
Ji, Kai
Song, Shuliang
author_facet Wang, Ke
Xu, Xueli
Wei, Qiang
Yang, Qiong
Zhao, Jiarui
Wang, Yuan
Li, Xia
Ji, Kai
Song, Shuliang
author_sort Wang, Ke
collection PubMed
description Fucoidan is a marine polysaccharide. In recent years, fucoidan has attracted wide-scale attention from the pharmaceutical industries due to its diverse biological activities such as lipid-lowering, anti-atherosclerosis, and anticoagulation. This review clarifies the pharmacological effects of fucoidan in the treatment of human cardiovascular and cerebrovascular diseases. Fucoidan exerts a hypolipidemic effect by increasing the reverse transport of cholesterol, inhibiting lipid synthesis, reducing lipid accumulation, and increasing lipid metabolism. Inflammation, anti-oxidation, and so on have a regulatory effect in the process of atherosclerosis endothelial cells, macrophages, smooth muscle cells, and so on; fucoidan can not only prevent thrombosis through anticoagulation and regulate platelet activation, but also promote the dissolution of formed thrombi. Fucoidan has a neuroprotective effect, and also has a positive effect on the prognosis of the cardiovascular and cerebrovascular. The prospects of applying fucoidan in cardio-cerebrovascular diseases are reviewed to provide some theoretical bases and inspirations for its full-scale development and utilization.
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spelling pubmed-90088572022-04-15 Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases Wang, Ke Xu, Xueli Wei, Qiang Yang, Qiong Zhao, Jiarui Wang, Yuan Li, Xia Ji, Kai Song, Shuliang Ther Adv Chronic Dis Review Fucoidan is a marine polysaccharide. In recent years, fucoidan has attracted wide-scale attention from the pharmaceutical industries due to its diverse biological activities such as lipid-lowering, anti-atherosclerosis, and anticoagulation. This review clarifies the pharmacological effects of fucoidan in the treatment of human cardiovascular and cerebrovascular diseases. Fucoidan exerts a hypolipidemic effect by increasing the reverse transport of cholesterol, inhibiting lipid synthesis, reducing lipid accumulation, and increasing lipid metabolism. Inflammation, anti-oxidation, and so on have a regulatory effect in the process of atherosclerosis endothelial cells, macrophages, smooth muscle cells, and so on; fucoidan can not only prevent thrombosis through anticoagulation and regulate platelet activation, but also promote the dissolution of formed thrombi. Fucoidan has a neuroprotective effect, and also has a positive effect on the prognosis of the cardiovascular and cerebrovascular. The prospects of applying fucoidan in cardio-cerebrovascular diseases are reviewed to provide some theoretical bases and inspirations for its full-scale development and utilization. SAGE Publications 2022-04-12 /pmc/articles/PMC9008857/ /pubmed/35432845 http://dx.doi.org/10.1177/20406223221076891 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Wang, Ke
Xu, Xueli
Wei, Qiang
Yang, Qiong
Zhao, Jiarui
Wang, Yuan
Li, Xia
Ji, Kai
Song, Shuliang
Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases
title Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases
title_full Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases
title_fullStr Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases
title_full_unstemmed Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases
title_short Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases
title_sort application of fucoidan as treatment for cardiovascular and cerebrovascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008857/
https://www.ncbi.nlm.nih.gov/pubmed/35432845
http://dx.doi.org/10.1177/20406223221076891
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