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Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases
Fucoidan is a marine polysaccharide. In recent years, fucoidan has attracted wide-scale attention from the pharmaceutical industries due to its diverse biological activities such as lipid-lowering, anti-atherosclerosis, and anticoagulation. This review clarifies the pharmacological effects of fucoid...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008857/ https://www.ncbi.nlm.nih.gov/pubmed/35432845 http://dx.doi.org/10.1177/20406223221076891 |
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author | Wang, Ke Xu, Xueli Wei, Qiang Yang, Qiong Zhao, Jiarui Wang, Yuan Li, Xia Ji, Kai Song, Shuliang |
author_facet | Wang, Ke Xu, Xueli Wei, Qiang Yang, Qiong Zhao, Jiarui Wang, Yuan Li, Xia Ji, Kai Song, Shuliang |
author_sort | Wang, Ke |
collection | PubMed |
description | Fucoidan is a marine polysaccharide. In recent years, fucoidan has attracted wide-scale attention from the pharmaceutical industries due to its diverse biological activities such as lipid-lowering, anti-atherosclerosis, and anticoagulation. This review clarifies the pharmacological effects of fucoidan in the treatment of human cardiovascular and cerebrovascular diseases. Fucoidan exerts a hypolipidemic effect by increasing the reverse transport of cholesterol, inhibiting lipid synthesis, reducing lipid accumulation, and increasing lipid metabolism. Inflammation, anti-oxidation, and so on have a regulatory effect in the process of atherosclerosis endothelial cells, macrophages, smooth muscle cells, and so on; fucoidan can not only prevent thrombosis through anticoagulation and regulate platelet activation, but also promote the dissolution of formed thrombi. Fucoidan has a neuroprotective effect, and also has a positive effect on the prognosis of the cardiovascular and cerebrovascular. The prospects of applying fucoidan in cardio-cerebrovascular diseases are reviewed to provide some theoretical bases and inspirations for its full-scale development and utilization. |
format | Online Article Text |
id | pubmed-9008857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-90088572022-04-15 Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases Wang, Ke Xu, Xueli Wei, Qiang Yang, Qiong Zhao, Jiarui Wang, Yuan Li, Xia Ji, Kai Song, Shuliang Ther Adv Chronic Dis Review Fucoidan is a marine polysaccharide. In recent years, fucoidan has attracted wide-scale attention from the pharmaceutical industries due to its diverse biological activities such as lipid-lowering, anti-atherosclerosis, and anticoagulation. This review clarifies the pharmacological effects of fucoidan in the treatment of human cardiovascular and cerebrovascular diseases. Fucoidan exerts a hypolipidemic effect by increasing the reverse transport of cholesterol, inhibiting lipid synthesis, reducing lipid accumulation, and increasing lipid metabolism. Inflammation, anti-oxidation, and so on have a regulatory effect in the process of atherosclerosis endothelial cells, macrophages, smooth muscle cells, and so on; fucoidan can not only prevent thrombosis through anticoagulation and regulate platelet activation, but also promote the dissolution of formed thrombi. Fucoidan has a neuroprotective effect, and also has a positive effect on the prognosis of the cardiovascular and cerebrovascular. The prospects of applying fucoidan in cardio-cerebrovascular diseases are reviewed to provide some theoretical bases and inspirations for its full-scale development and utilization. SAGE Publications 2022-04-12 /pmc/articles/PMC9008857/ /pubmed/35432845 http://dx.doi.org/10.1177/20406223221076891 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Wang, Ke Xu, Xueli Wei, Qiang Yang, Qiong Zhao, Jiarui Wang, Yuan Li, Xia Ji, Kai Song, Shuliang Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases |
title | Application of fucoidan as treatment for cardiovascular and
cerebrovascular diseases |
title_full | Application of fucoidan as treatment for cardiovascular and
cerebrovascular diseases |
title_fullStr | Application of fucoidan as treatment for cardiovascular and
cerebrovascular diseases |
title_full_unstemmed | Application of fucoidan as treatment for cardiovascular and
cerebrovascular diseases |
title_short | Application of fucoidan as treatment for cardiovascular and
cerebrovascular diseases |
title_sort | application of fucoidan as treatment for cardiovascular and
cerebrovascular diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008857/ https://www.ncbi.nlm.nih.gov/pubmed/35432845 http://dx.doi.org/10.1177/20406223221076891 |
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