A phase 1 study of the safety, pharmacokinetics and pharmacodynamics of escalating doses followed by dose expansion of the selective inhibitor of nuclear export (SINE) selinexor in Asian patients with advanced or metastatic malignancies

PURPOSE: This phase 1 study aims to evaluate the tolerability and the recommended phase 2 dose of selinexor in Asian patients with advanced or metastatic malignancies. EXPERIMENTAL DESIGN: A total of 105 patients with advanced malignancies were enrolled from two sites in Singapore (National Universi...

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Autores principales: Ho, Jingshan, Heong, Valerie, Peng Yong, Wei, Soo, Ross, Ean Chee, Cheng, Wong, Andrea, Sundar, Raghav, Liang Thian, Yee, Gopinathan, Anil, Yan Pang, Mei, Koe, Priscillia, Nathan Jeraj, Santhiay, Pyar Soe, Phyu, Yar Soe, Mu, Tang, Tiffany, Ng, Matthew C.H., Tai, David W.M., Tan, Tira J.Y., Xu, Hongmei, Chang, Hua, Landesman, Yosef, Shah, Jatin, Shacham, Sharon, Chin Lee, Soo, Tan, Daniel S.W., Cher Goh, Boon, Tan, David S.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008867/
https://www.ncbi.nlm.nih.gov/pubmed/35432603
http://dx.doi.org/10.1177/17588359221087555

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