Cargando…
Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function
Parkinson's disease (PD) is an age‐related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, associated with the accumulation of misfolded α‐synuclein and lysosomal impairment, two events deemed interconnected. Protein aggregation is linked to...
Autores principales: | Arotcarena, Marie‐Laure, Soria, Federico N., Cunha, Anthony, Doudnikoff, Evelyne, Prévot, Geoffrey, Daniel, Jonathan, Blanchard‐Desce, Mireille, Barthélémy, Philippe, Bezard, Erwan, Crauste‐Manciet, Sylvie, Dehay, Benjamin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009122/ https://www.ncbi.nlm.nih.gov/pubmed/35318803 http://dx.doi.org/10.1111/acel.13584 |
Ejemplares similares
-
Nucleolipid Acid-Based Nanocarriers Restore Neuronal Lysosomal Acidification Defects
por: Brouillard, Mathias, et al.
Publicado: (2021) -
Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
por: Arotcarena, Marie-Laure, et al.
Publicado: (2019) -
Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts
por: Teil, Margaux, et al.
Publicado: (2020) -
Synthesis and Intracellular Uptake of Rhodamine–Nucleolipid
Conjugates into a Nanoemulsion Vehicle
por: Cunha, Anthony, et al.
Publicado: (2020) -
Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death
por: Bourdenx, Mathieu, et al.
Publicado: (2014)