Different responses to DNA damage determine ageing differences between organs

Organs age differently, causing wide heterogeneity in multimorbidity, but underlying mechanisms are largely elusive. To investigate the basis of organ‐specific ageing, we utilized progeroid repair‐deficient Ercc1(Δ) (/−) mouse mutants and systematically compared at the tissue, stem cell and organoid...

Descripción completa

Detalles Bibliográficos
Autores principales: Vougioukalaki, Maria, Demmers, Joris, Vermeij, Wilbert P., Baar, Marjolein, Bruens, Serena, Magaraki, Aristea, Kuijk, Ewart, Jager, Myrthe, Merzouk, Sarra, Brandt, Renata M.C., Kouwenberg, Janneke, van Boxtel, Ruben, Cuppen, Edwin, Pothof, Joris, Hoeijmakers, Jan H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009128/
https://www.ncbi.nlm.nih.gov/pubmed/35246937
http://dx.doi.org/10.1111/acel.13562

Ejemplares similares

Ejemplares similares