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Case Report: Cerebral Venous Sinus Thrombosis in a Young Child With SARS-CoV-2 Infection: The Italian Experience

INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric patients is usually characterized by fever, dry cough, and fatigue, or is asymptomatic and rarely presents with pneumonia. On the other hand, cerebral venous sinus thrombosis (CVST) could be a neurologi...

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Autores principales: Silvestri, Paola, Clemente, Anna, Spalice, Alberto, Febbo, Alessandra, Matera, Luigi, Accardo, Fabiana, Barbieri, Maria Antonietta, Villani, Alberto, Midulla, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009147/
https://www.ncbi.nlm.nih.gov/pubmed/35432183
http://dx.doi.org/10.3389/fneur.2022.861345
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author Silvestri, Paola
Clemente, Anna
Spalice, Alberto
Febbo, Alessandra
Matera, Luigi
Accardo, Fabiana
Barbieri, Maria Antonietta
Villani, Alberto
Midulla, Fabio
author_facet Silvestri, Paola
Clemente, Anna
Spalice, Alberto
Febbo, Alessandra
Matera, Luigi
Accardo, Fabiana
Barbieri, Maria Antonietta
Villani, Alberto
Midulla, Fabio
author_sort Silvestri, Paola
collection PubMed
description INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric patients is usually characterized by fever, dry cough, and fatigue, or is asymptomatic and rarely presents with pneumonia. On the other hand, cerebral venous sinus thrombosis (CVST) could be a neurological sequela of the prothrombotic state triggered by coronavirus disease 2019 (COVID-19) both in adults and children. CASE REPORT: We present a case of a 15-year-old male child who was obese and had mild neurocognitive impairment. He was admitted to the pediatric emergency department and then diagnosed with CVST during SARS-CoV-2 infection. CONCLUSION: During the COVID-19 pandemic, in patients presenting with neurological manifestations of CVST (headache, alteration of consciousness, focal deficit, or signs of endocranial hypertension), it is advisable to look for a current or recent infection of SARS-CoV-2, regardless of the presence of respiratory symptoms. In our patient, ongoing SARS-CoV-2 infection represents the only prothrombotic risk factor underlying the neurological disease.
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spelling pubmed-90091472022-04-15 Case Report: Cerebral Venous Sinus Thrombosis in a Young Child With SARS-CoV-2 Infection: The Italian Experience Silvestri, Paola Clemente, Anna Spalice, Alberto Febbo, Alessandra Matera, Luigi Accardo, Fabiana Barbieri, Maria Antonietta Villani, Alberto Midulla, Fabio Front Neurol Neurology INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric patients is usually characterized by fever, dry cough, and fatigue, or is asymptomatic and rarely presents with pneumonia. On the other hand, cerebral venous sinus thrombosis (CVST) could be a neurological sequela of the prothrombotic state triggered by coronavirus disease 2019 (COVID-19) both in adults and children. CASE REPORT: We present a case of a 15-year-old male child who was obese and had mild neurocognitive impairment. He was admitted to the pediatric emergency department and then diagnosed with CVST during SARS-CoV-2 infection. CONCLUSION: During the COVID-19 pandemic, in patients presenting with neurological manifestations of CVST (headache, alteration of consciousness, focal deficit, or signs of endocranial hypertension), it is advisable to look for a current or recent infection of SARS-CoV-2, regardless of the presence of respiratory symptoms. In our patient, ongoing SARS-CoV-2 infection represents the only prothrombotic risk factor underlying the neurological disease. Frontiers Media S.A. 2022-03-31 /pmc/articles/PMC9009147/ /pubmed/35432183 http://dx.doi.org/10.3389/fneur.2022.861345 Text en Copyright © 2022 Silvestri, Clemente, Spalice, Febbo, Matera, Accardo, Barbieri, Villani and Midulla. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Silvestri, Paola
Clemente, Anna
Spalice, Alberto
Febbo, Alessandra
Matera, Luigi
Accardo, Fabiana
Barbieri, Maria Antonietta
Villani, Alberto
Midulla, Fabio
Case Report: Cerebral Venous Sinus Thrombosis in a Young Child With SARS-CoV-2 Infection: The Italian Experience
title Case Report: Cerebral Venous Sinus Thrombosis in a Young Child With SARS-CoV-2 Infection: The Italian Experience
title_full Case Report: Cerebral Venous Sinus Thrombosis in a Young Child With SARS-CoV-2 Infection: The Italian Experience
title_fullStr Case Report: Cerebral Venous Sinus Thrombosis in a Young Child With SARS-CoV-2 Infection: The Italian Experience
title_full_unstemmed Case Report: Cerebral Venous Sinus Thrombosis in a Young Child With SARS-CoV-2 Infection: The Italian Experience
title_short Case Report: Cerebral Venous Sinus Thrombosis in a Young Child With SARS-CoV-2 Infection: The Italian Experience
title_sort case report: cerebral venous sinus thrombosis in a young child with sars-cov-2 infection: the italian experience
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009147/
https://www.ncbi.nlm.nih.gov/pubmed/35432183
http://dx.doi.org/10.3389/fneur.2022.861345
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