Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages

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Genome-wide association studies have identified 3p21.31 as the main risk locus for severe COVID-19, although underlying mechanisms remain elusive. We perform an epigenomic dissection of 3p21.31, identifying a CTCF-dependent tissue-specific 3D regulatory chromatin hub that controls the activity of se...

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Detalles Bibliográficos
Autores principales: Stikker, Bernard S., Stik, Grégoire, van Ouwerkerk, Antoinette F., Trap, Lianne, Spicuglia, Salvatore, Hendriks, Rudi W., Stadhouders, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009160/
https://www.ncbi.nlm.nih.gov/pubmed/35421995
http://dx.doi.org/10.1186/s13059-022-02669-z
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