Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways

Circular RNAs (circRNAs) are highly expressed in the central nervous system and have been reported to be associated with neuropsychiatric diseases, but their potential role in major depressive disorder (MDD) remains unclear. Here, we demonstrated that there was a disorder of circRNAs in the blood of...

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Autores principales: Zhang, Dandan, Ji, Yao, Chen, Xiongjin, Chen, RunSen, Wei, Yaxue, Peng, Qian, Lin, Juda, Yin, Jingwen, Li, Hezhan, Cui, Lili, Lin, Zhixiong, Cai, Yujie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009243/
https://www.ncbi.nlm.nih.gov/pubmed/35431783
http://dx.doi.org/10.3389/fnins.2022.844422
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author Zhang, Dandan
Ji, Yao
Chen, Xiongjin
Chen, RunSen
Wei, Yaxue
Peng, Qian
Lin, Juda
Yin, Jingwen
Li, Hezhan
Cui, Lili
Lin, Zhixiong
Cai, Yujie
author_facet Zhang, Dandan
Ji, Yao
Chen, Xiongjin
Chen, RunSen
Wei, Yaxue
Peng, Qian
Lin, Juda
Yin, Jingwen
Li, Hezhan
Cui, Lili
Lin, Zhixiong
Cai, Yujie
author_sort Zhang, Dandan
collection PubMed
description Circular RNAs (circRNAs) are highly expressed in the central nervous system and have been reported to be associated with neuropsychiatric diseases, but their potential role in major depressive disorder (MDD) remains unclear. Here, we demonstrated that there was a disorder of circRNAs in the blood of MDD patients. It has been preliminarily proved that hsa_circ_0002473, hsa_circ_0079651, hsa_circ_0137187, hsa_circ_0006010, and hsa_circ_0113010 were highly expressed in MDD patients and can be used as diagnostic markers for MDD. Bioinformatics analysis revealed that hsa_circ_0079651, hsa_circ_0137187, hsa_circ_0006010, and hsa_circ_0113010 may affect the neuroplasticity of MDD through the ceRNA mechanism.
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spelling pubmed-90092432022-04-15 Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways Zhang, Dandan Ji, Yao Chen, Xiongjin Chen, RunSen Wei, Yaxue Peng, Qian Lin, Juda Yin, Jingwen Li, Hezhan Cui, Lili Lin, Zhixiong Cai, Yujie Front Neurosci Neuroscience Circular RNAs (circRNAs) are highly expressed in the central nervous system and have been reported to be associated with neuropsychiatric diseases, but their potential role in major depressive disorder (MDD) remains unclear. Here, we demonstrated that there was a disorder of circRNAs in the blood of MDD patients. It has been preliminarily proved that hsa_circ_0002473, hsa_circ_0079651, hsa_circ_0137187, hsa_circ_0006010, and hsa_circ_0113010 were highly expressed in MDD patients and can be used as diagnostic markers for MDD. Bioinformatics analysis revealed that hsa_circ_0079651, hsa_circ_0137187, hsa_circ_0006010, and hsa_circ_0113010 may affect the neuroplasticity of MDD through the ceRNA mechanism. Frontiers Media S.A. 2022-03-31 /pmc/articles/PMC9009243/ /pubmed/35431783 http://dx.doi.org/10.3389/fnins.2022.844422 Text en Copyright © 2022 Zhang, Ji, Chen, Chen, Wei, Peng, Lin, Yin, Li, Cui, Lin and Cai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Dandan
Ji, Yao
Chen, Xiongjin
Chen, RunSen
Wei, Yaxue
Peng, Qian
Lin, Juda
Yin, Jingwen
Li, Hezhan
Cui, Lili
Lin, Zhixiong
Cai, Yujie
Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways
title Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways
title_full Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways
title_fullStr Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways
title_full_unstemmed Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways
title_short Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways
title_sort peripheral blood circular rnas as a biomarker for major depressive disorder and prediction of possible pathways
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009243/
https://www.ncbi.nlm.nih.gov/pubmed/35431783
http://dx.doi.org/10.3389/fnins.2022.844422
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