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Brown Adipose Tissue Prevalence Is Lower in Obesity but Its Metabolic Activity Is Intact

Due to its high metabolic activity, brown adipose tissue (BAT) has become a promising target for the development of novel treatment concepts for metabolic disease. Despite several reports of a negative association between the presence of active BAT and obesity, very little is known about the quantit...

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Autores principales: Kulterer, Oana C., Herz, Carsten T., Prager, Marlene, Schmöltzer, Christoph, Langer, Felix B., Prager, Gerhard, Marculescu, Rodrig, Kautzky-Willer, Alexandra, Hacker, Marcus, Haug, Alexander R., Kiefer, Florian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009254/
https://www.ncbi.nlm.nih.gov/pubmed/35432192
http://dx.doi.org/10.3389/fendo.2022.858417
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author Kulterer, Oana C.
Herz, Carsten T.
Prager, Marlene
Schmöltzer, Christoph
Langer, Felix B.
Prager, Gerhard
Marculescu, Rodrig
Kautzky-Willer, Alexandra
Hacker, Marcus
Haug, Alexander R.
Kiefer, Florian W.
author_facet Kulterer, Oana C.
Herz, Carsten T.
Prager, Marlene
Schmöltzer, Christoph
Langer, Felix B.
Prager, Gerhard
Marculescu, Rodrig
Kautzky-Willer, Alexandra
Hacker, Marcus
Haug, Alexander R.
Kiefer, Florian W.
author_sort Kulterer, Oana C.
collection PubMed
description Due to its high metabolic activity, brown adipose tissue (BAT) has become a promising target for the development of novel treatment concepts for metabolic disease. Despite several reports of a negative association between the presence of active BAT and obesity, very little is known about the quantitative and qualitative differences of BAT in lean and obese individuals. Systematic studies directly comparing cold-induced BAT activity in leanness and obesity are currently lacking. Here we studied BAT mass and function in 31 lean and 64 obese men and women. After a standardized cooling protocol using a water-perfused vest, (18)F-FDG-positron emission tomography/computed tomography scans were performed, and BAT was delineated using lean body-mass adjusted standardized uptake value (SUV) thresholds in anatomic regions with fat radiodensity. Cold-induced thermogenesis (CIT), a functional readout of BAT activity, was quantified by indirect calorimetry. Active BAT was present in a significantly higher proportion of lean than obese individuals (58% vs. 33%, p=0.019). In these participants with active BAT, however, BAT volume and activity did not differ between leanness and obesity. Accordingly, CIT was similar in both weight groups. BAT metrics were not related to adiposity or total fat mass per se. However, in obese participants a strong negative correlation existed between visceral adipose tissue and BAT volume, (18)F-FDG uptake and CIT. In summary, despite a significantly lower prevalence of BAT, the metabolic activity and thermogenic capacity of BAT appears to be still intact in obesity and is inversely associated with visceral fat mass.
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spelling pubmed-90092542022-04-15 Brown Adipose Tissue Prevalence Is Lower in Obesity but Its Metabolic Activity Is Intact Kulterer, Oana C. Herz, Carsten T. Prager, Marlene Schmöltzer, Christoph Langer, Felix B. Prager, Gerhard Marculescu, Rodrig Kautzky-Willer, Alexandra Hacker, Marcus Haug, Alexander R. Kiefer, Florian W. Front Endocrinol (Lausanne) Endocrinology Due to its high metabolic activity, brown adipose tissue (BAT) has become a promising target for the development of novel treatment concepts for metabolic disease. Despite several reports of a negative association between the presence of active BAT and obesity, very little is known about the quantitative and qualitative differences of BAT in lean and obese individuals. Systematic studies directly comparing cold-induced BAT activity in leanness and obesity are currently lacking. Here we studied BAT mass and function in 31 lean and 64 obese men and women. After a standardized cooling protocol using a water-perfused vest, (18)F-FDG-positron emission tomography/computed tomography scans were performed, and BAT was delineated using lean body-mass adjusted standardized uptake value (SUV) thresholds in anatomic regions with fat radiodensity. Cold-induced thermogenesis (CIT), a functional readout of BAT activity, was quantified by indirect calorimetry. Active BAT was present in a significantly higher proportion of lean than obese individuals (58% vs. 33%, p=0.019). In these participants with active BAT, however, BAT volume and activity did not differ between leanness and obesity. Accordingly, CIT was similar in both weight groups. BAT metrics were not related to adiposity or total fat mass per se. However, in obese participants a strong negative correlation existed between visceral adipose tissue and BAT volume, (18)F-FDG uptake and CIT. In summary, despite a significantly lower prevalence of BAT, the metabolic activity and thermogenic capacity of BAT appears to be still intact in obesity and is inversely associated with visceral fat mass. Frontiers Media S.A. 2022-03-31 /pmc/articles/PMC9009254/ /pubmed/35432192 http://dx.doi.org/10.3389/fendo.2022.858417 Text en Copyright © 2022 Kulterer, Herz, Prager, Schmöltzer, Langer, Prager, Marculescu, Kautzky-Willer, Hacker, Haug and Kiefer https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Kulterer, Oana C.
Herz, Carsten T.
Prager, Marlene
Schmöltzer, Christoph
Langer, Felix B.
Prager, Gerhard
Marculescu, Rodrig
Kautzky-Willer, Alexandra
Hacker, Marcus
Haug, Alexander R.
Kiefer, Florian W.
Brown Adipose Tissue Prevalence Is Lower in Obesity but Its Metabolic Activity Is Intact
title Brown Adipose Tissue Prevalence Is Lower in Obesity but Its Metabolic Activity Is Intact
title_full Brown Adipose Tissue Prevalence Is Lower in Obesity but Its Metabolic Activity Is Intact
title_fullStr Brown Adipose Tissue Prevalence Is Lower in Obesity but Its Metabolic Activity Is Intact
title_full_unstemmed Brown Adipose Tissue Prevalence Is Lower in Obesity but Its Metabolic Activity Is Intact
title_short Brown Adipose Tissue Prevalence Is Lower in Obesity but Its Metabolic Activity Is Intact
title_sort brown adipose tissue prevalence is lower in obesity but its metabolic activity is intact
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009254/
https://www.ncbi.nlm.nih.gov/pubmed/35432192
http://dx.doi.org/10.3389/fendo.2022.858417
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