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Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review

BACKGROUND: Lipids are ubiquitous metabolites with diverse functions. Excessive lipid accumulation can trigger lipid redistribution among metabolic organs such as adipose, liver and muscle, thus altering the lipid metabolism. It has been revealed that disturbed lipid metabolism would cause multiple...

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Autores principales: Zhou, Qian, Wang, Yanmei, Han, Xuke, Fu, Shunlian, Zhu, Chan, Chen, Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009313/
https://www.ncbi.nlm.nih.gov/pubmed/35431994
http://dx.doi.org/10.3389/fphys.2022.795980
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author Zhou, Qian
Wang, Yanmei
Han, Xuke
Fu, Shunlian
Zhu, Chan
Chen, Qiu
author_facet Zhou, Qian
Wang, Yanmei
Han, Xuke
Fu, Shunlian
Zhu, Chan
Chen, Qiu
author_sort Zhou, Qian
collection PubMed
description BACKGROUND: Lipids are ubiquitous metabolites with diverse functions. Excessive lipid accumulation can trigger lipid redistribution among metabolic organs such as adipose, liver and muscle, thus altering the lipid metabolism. It has been revealed that disturbed lipid metabolism would cause multiple disease complications and is highly correlated with human morbidity. Resveratrol (RSV), a phytoestrogen with antioxidant, can modulate insulin resistance and lipid profile. Recently, research on RSV supplementation to improve glucose and lipid metabolism has been controversial. A meta-analysis may provide a scientific reference for the relationship between lipid metabolism and RSV supplementation. METHODS AND ANALYSIS: We searched the PubMed, Cochrane Library, Web of Science, and Embase databases from inception to October 2021 using relevant keywords. A comprehensive search for randomized controlled trials (RCTs) was performed. For calculating pooled effects, continuous data were pooled by mean difference (MD) and 95% confidence interval (CI). Adopting the method of inverse-variance with a random-effect, all related statistical analyses were performed using the Rev Man V.5.3 and STATA V.15 software. RESULTS: A total of 25 articles were incorporated into the final meta-analysis after removal of duplicates by checking titles and abstracts and excluding non-relevant articles. The selected articles had a total of 1,171 participants, including 578 in the placebo group and 593 in the intervention group. According to the current meta-analysis, which demonstrated that there was a significant decrease in waist circumference (SMD = –0.36; 95% CI: –0.59, –0.14; P = 0.002; I(2) = 88%), hemoglobin A1c (–0.48; –0.69, –0.27; P ≤ 0.001; I(2) = 94%), total cholesterol (–0.15; –0.3, –0.01; P = 0.003; I(2) = 94%), low density lipoprotein cholesterol (–0.42; –0.57, –0.27; P ≤ 0.001; I(2) = 92%), high density lipoprotein cholesterol (0.16; –0.31, –0.02; P = 0.03; I(2) = 81%) following resveratrol administration. CONCLUSION: These results suggest that RSV has a dramatic impact on regulating lipid and glucose metabolism, and the major clinical value of resveratrol intake is for obese and diabetic patients. We hope that this study could provide more options for clinicians using RSV. Furthermore, in the future, large-scale and well-designed trials will be warranted to confirm these results. SYSTEMATIC REVIEW REGISTRATION: Website [https://www.crd.york.ac.uk/prospero/#recordDetails], identifier [CRD42021244904].
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spelling pubmed-90093132022-04-15 Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review Zhou, Qian Wang, Yanmei Han, Xuke Fu, Shunlian Zhu, Chan Chen, Qiu Front Physiol Physiology BACKGROUND: Lipids are ubiquitous metabolites with diverse functions. Excessive lipid accumulation can trigger lipid redistribution among metabolic organs such as adipose, liver and muscle, thus altering the lipid metabolism. It has been revealed that disturbed lipid metabolism would cause multiple disease complications and is highly correlated with human morbidity. Resveratrol (RSV), a phytoestrogen with antioxidant, can modulate insulin resistance and lipid profile. Recently, research on RSV supplementation to improve glucose and lipid metabolism has been controversial. A meta-analysis may provide a scientific reference for the relationship between lipid metabolism and RSV supplementation. METHODS AND ANALYSIS: We searched the PubMed, Cochrane Library, Web of Science, and Embase databases from inception to October 2021 using relevant keywords. A comprehensive search for randomized controlled trials (RCTs) was performed. For calculating pooled effects, continuous data were pooled by mean difference (MD) and 95% confidence interval (CI). Adopting the method of inverse-variance with a random-effect, all related statistical analyses were performed using the Rev Man V.5.3 and STATA V.15 software. RESULTS: A total of 25 articles were incorporated into the final meta-analysis after removal of duplicates by checking titles and abstracts and excluding non-relevant articles. The selected articles had a total of 1,171 participants, including 578 in the placebo group and 593 in the intervention group. According to the current meta-analysis, which demonstrated that there was a significant decrease in waist circumference (SMD = –0.36; 95% CI: –0.59, –0.14; P = 0.002; I(2) = 88%), hemoglobin A1c (–0.48; –0.69, –0.27; P ≤ 0.001; I(2) = 94%), total cholesterol (–0.15; –0.3, –0.01; P = 0.003; I(2) = 94%), low density lipoprotein cholesterol (–0.42; –0.57, –0.27; P ≤ 0.001; I(2) = 92%), high density lipoprotein cholesterol (0.16; –0.31, –0.02; P = 0.03; I(2) = 81%) following resveratrol administration. CONCLUSION: These results suggest that RSV has a dramatic impact on regulating lipid and glucose metabolism, and the major clinical value of resveratrol intake is for obese and diabetic patients. We hope that this study could provide more options for clinicians using RSV. Furthermore, in the future, large-scale and well-designed trials will be warranted to confirm these results. SYSTEMATIC REVIEW REGISTRATION: Website [https://www.crd.york.ac.uk/prospero/#recordDetails], identifier [CRD42021244904]. Frontiers Media S.A. 2022-03-31 /pmc/articles/PMC9009313/ /pubmed/35431994 http://dx.doi.org/10.3389/fphys.2022.795980 Text en Copyright © 2022 Zhou, Wang, Han, Fu, Zhu and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zhou, Qian
Wang, Yanmei
Han, Xuke
Fu, Shunlian
Zhu, Chan
Chen, Qiu
Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review
title Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review
title_full Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review
title_fullStr Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review
title_full_unstemmed Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review
title_short Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review
title_sort efficacy of resveratrol supplementation on glucose and lipid metabolism: a meta-analysis and systematic review
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009313/
https://www.ncbi.nlm.nih.gov/pubmed/35431994
http://dx.doi.org/10.3389/fphys.2022.795980
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