Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy

BACKGROUND: Despite a successful antiretroviral therapy (ART), adolescents living with perinatally acquired HIV (PHIV) experience signs of B-cell hyperactivation with expansion of ‘namely’ atypical B-cell phenotypes, including double negative (CD27-IgD-) and termed age associated (ABCs) B-cells (T-b...

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Detalles Bibliográficos
Autores principales: Ruggiero, Alessandra, Pascucci, Giuseppe Rubens, Cotugno, Nicola, Domínguez-Rodríguez, Sara, Rinaldi, Stefano, Tagarro, Alfredo, Rojo, Pablo, Foster, Caroline, Bamford, Alasdair, De Rossi, Anita, Nastouli, Eleni, Klein, Nigel, Morrocchi, Elena, Fatou, Benoit, Smolen, Kinga K., Ozonoff, Al, Di Pastena, Michela, Luzuriaga, Katherine, Steen, Hanno, Giaquinto, Carlo, Goulder, Philip, Rossi, Paolo, Levy, Ofer, Pahwa, Savita, Palma, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009387/
https://www.ncbi.nlm.nih.gov/pubmed/35432380
http://dx.doi.org/10.3389/fimmu.2022.860418

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