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The Measurement Performance of the Parkinson's Disease Activities of Daily Living, Interference, and Dependence Instrument
Parkinson's disease is a neurodegenerative disease that can be associated with motor fluctuations that result in substantial negative impact to an individual's activities of daily living. Understanding the patient's perspective about the impact of Parkinson's disease therapies is...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009412/ https://www.ncbi.nlm.nih.gov/pubmed/35432147 http://dx.doi.org/10.3389/fneur.2022.760174 |
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author | Deal, Linda S. Andrae, David A. Myers, Daniela E. Johnson, Nathan Foster, Brandon Evans, Christopher J. |
author_facet | Deal, Linda S. Andrae, David A. Myers, Daniela E. Johnson, Nathan Foster, Brandon Evans, Christopher J. |
author_sort | Deal, Linda S. |
collection | PubMed |
description | Parkinson's disease is a neurodegenerative disease that can be associated with motor fluctuations that result in substantial negative impact to an individual's activities of daily living. Understanding the patient's perspective about the impact of Parkinson's disease therapies is an important part of drug development and shared treatment decision-making. The objective of this research was to examine the structure, scoring, internal consistency, test-retest reliability, and concurrent and known groups validity of the Parkinson's Disease Activities of Daily Living, Interference and Dependence (PD-AID) instrument, a new, patient-reported outcomes instrument, developed to assess the clinical benefit of Parkinson's disease treatment from the patient's perspective. This was a non-interventional study among persons with mild-to-moderate Parkinson's disease currently using and responding to L-Dopa. The structure of the measure was confirmed applying item response theory to data from baseline, supporting 4 candidate scores. Baseline Patient Global Impression of Severity ratings facilitated known-groups analysis. Data from all participants were used to estimate test-retest reliability. Concurrent validity was assessed using correlations with related measures. Participants (n = 94) were mean age 69 years (mean time since diagnosis 6.9 years); 34 experienced L-Dopa-related dyskinesia. Psychometric models supported 4 candidate scoring regimes for the PD-AID. All exhibited adequate reliability and validity characteristics and strong internal consistency. Correlations with reference measures were in the expected direction and range of magnitude. Analyses supported the PD-AID as fit-for-purpose, producing psychometrically sound scores. Further research to confirm the measurement properties of the PD-AID in an expanded sample and to establish thresholds for meaningful score changes is recommended. |
format | Online Article Text |
id | pubmed-9009412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90094122022-04-15 The Measurement Performance of the Parkinson's Disease Activities of Daily Living, Interference, and Dependence Instrument Deal, Linda S. Andrae, David A. Myers, Daniela E. Johnson, Nathan Foster, Brandon Evans, Christopher J. Front Neurol Neurology Parkinson's disease is a neurodegenerative disease that can be associated with motor fluctuations that result in substantial negative impact to an individual's activities of daily living. Understanding the patient's perspective about the impact of Parkinson's disease therapies is an important part of drug development and shared treatment decision-making. The objective of this research was to examine the structure, scoring, internal consistency, test-retest reliability, and concurrent and known groups validity of the Parkinson's Disease Activities of Daily Living, Interference and Dependence (PD-AID) instrument, a new, patient-reported outcomes instrument, developed to assess the clinical benefit of Parkinson's disease treatment from the patient's perspective. This was a non-interventional study among persons with mild-to-moderate Parkinson's disease currently using and responding to L-Dopa. The structure of the measure was confirmed applying item response theory to data from baseline, supporting 4 candidate scores. Baseline Patient Global Impression of Severity ratings facilitated known-groups analysis. Data from all participants were used to estimate test-retest reliability. Concurrent validity was assessed using correlations with related measures. Participants (n = 94) were mean age 69 years (mean time since diagnosis 6.9 years); 34 experienced L-Dopa-related dyskinesia. Psychometric models supported 4 candidate scoring regimes for the PD-AID. All exhibited adequate reliability and validity characteristics and strong internal consistency. Correlations with reference measures were in the expected direction and range of magnitude. Analyses supported the PD-AID as fit-for-purpose, producing psychometrically sound scores. Further research to confirm the measurement properties of the PD-AID in an expanded sample and to establish thresholds for meaningful score changes is recommended. Frontiers Media S.A. 2022-03-31 /pmc/articles/PMC9009412/ /pubmed/35432147 http://dx.doi.org/10.3389/fneur.2022.760174 Text en Copyright © 2022 Deal, Andrae, Myers, Johnson, Foster and Evans. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Deal, Linda S. Andrae, David A. Myers, Daniela E. Johnson, Nathan Foster, Brandon Evans, Christopher J. The Measurement Performance of the Parkinson's Disease Activities of Daily Living, Interference, and Dependence Instrument |
title | The Measurement Performance of the Parkinson's Disease Activities of Daily Living, Interference, and Dependence Instrument |
title_full | The Measurement Performance of the Parkinson's Disease Activities of Daily Living, Interference, and Dependence Instrument |
title_fullStr | The Measurement Performance of the Parkinson's Disease Activities of Daily Living, Interference, and Dependence Instrument |
title_full_unstemmed | The Measurement Performance of the Parkinson's Disease Activities of Daily Living, Interference, and Dependence Instrument |
title_short | The Measurement Performance of the Parkinson's Disease Activities of Daily Living, Interference, and Dependence Instrument |
title_sort | measurement performance of the parkinson's disease activities of daily living, interference, and dependence instrument |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009412/ https://www.ncbi.nlm.nih.gov/pubmed/35432147 http://dx.doi.org/10.3389/fneur.2022.760174 |
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