Macrocytic Anaemia: Not Always a Straightforward Diagnosis

Macrocytosis is defined as a mean corpuscular volume greater than 100 femtolitres (fL). There are several causes for macrocytic anaemia, and they can be divided into megaloblastic or non-megaloblastic anaemia. Vitamin B12 deficiency is one of the most common causes of megaloblastic anaemia. The caus...

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Autores principales: Teixeira, Andreia M, Macedo, Bernardo, Fontes, Carla P, Manuel, Micaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010004/
https://www.ncbi.nlm.nih.gov/pubmed/35444885
http://dx.doi.org/10.7759/cureus.23152
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author Teixeira, Andreia M
Macedo, Bernardo
Fontes, Carla P
Manuel, Micaela
author_facet Teixeira, Andreia M
Macedo, Bernardo
Fontes, Carla P
Manuel, Micaela
author_sort Teixeira, Andreia M
collection PubMed
description Macrocytosis is defined as a mean corpuscular volume greater than 100 femtolitres (fL). There are several causes for macrocytic anaemia, and they can be divided into megaloblastic or non-megaloblastic anaemia. Vitamin B12 deficiency is one of the most common causes of megaloblastic anaemia. The cause of vitamin B12 deficiency must be evaluated including the presence of pernicious anaemia as it could alter the treatment and follow-up. Pernicious anaemia can be associated with other autoimmune diseases constituting polyglandular syndromes.
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spelling pubmed-90100042022-04-19 Macrocytic Anaemia: Not Always a Straightforward Diagnosis Teixeira, Andreia M Macedo, Bernardo Fontes, Carla P Manuel, Micaela Cureus Endocrinology/Diabetes/Metabolism Macrocytosis is defined as a mean corpuscular volume greater than 100 femtolitres (fL). There are several causes for macrocytic anaemia, and they can be divided into megaloblastic or non-megaloblastic anaemia. Vitamin B12 deficiency is one of the most common causes of megaloblastic anaemia. The cause of vitamin B12 deficiency must be evaluated including the presence of pernicious anaemia as it could alter the treatment and follow-up. Pernicious anaemia can be associated with other autoimmune diseases constituting polyglandular syndromes. Cureus 2022-03-14 /pmc/articles/PMC9010004/ /pubmed/35444885 http://dx.doi.org/10.7759/cureus.23152 Text en Copyright © 2022, Teixeira et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Teixeira, Andreia M
Macedo, Bernardo
Fontes, Carla P
Manuel, Micaela
Macrocytic Anaemia: Not Always a Straightforward Diagnosis
title Macrocytic Anaemia: Not Always a Straightforward Diagnosis
title_full Macrocytic Anaemia: Not Always a Straightforward Diagnosis
title_fullStr Macrocytic Anaemia: Not Always a Straightforward Diagnosis
title_full_unstemmed Macrocytic Anaemia: Not Always a Straightforward Diagnosis
title_short Macrocytic Anaemia: Not Always a Straightforward Diagnosis
title_sort macrocytic anaemia: not always a straightforward diagnosis
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010004/
https://www.ncbi.nlm.nih.gov/pubmed/35444885
http://dx.doi.org/10.7759/cureus.23152
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