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Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth

Phthalates are a diverse group of chemicals used in consumer products. Because they are so widespread, exposure to these compounds is nearly unavoidable. Recently, growing scientific consensus has suggested that phthalates produce health effects in developing infants and children. These effects may...

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Autores principales: Petroff, Rebekah L., Padmanabhan, Vasantha, Dolinoy, Dana C., Watkins, Deborah J., Ciarelli, Joseph, Haggerty, Diana, Ruden, Douglas M., Goodrich, Jaclyn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010032/
https://www.ncbi.nlm.nih.gov/pubmed/35432478
http://dx.doi.org/10.3389/fgene.2022.793278
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author Petroff, Rebekah L.
Padmanabhan, Vasantha
Dolinoy, Dana C.
Watkins, Deborah J.
Ciarelli, Joseph
Haggerty, Diana
Ruden, Douglas M.
Goodrich, Jaclyn M.
author_facet Petroff, Rebekah L.
Padmanabhan, Vasantha
Dolinoy, Dana C.
Watkins, Deborah J.
Ciarelli, Joseph
Haggerty, Diana
Ruden, Douglas M.
Goodrich, Jaclyn M.
author_sort Petroff, Rebekah L.
collection PubMed
description Phthalates are a diverse group of chemicals used in consumer products. Because they are so widespread, exposure to these compounds is nearly unavoidable. Recently, growing scientific consensus has suggested that phthalates produce health effects in developing infants and children. These effects may be mediated through mechanisms related to the epigenome, the constellation of mitotically heritable chemical marks and small compounds that guide transcription and translation. The present study examined the relationship between prenatal, first-trimester exposure of seven phthalates and epigenetics in two pregnancy cohorts (n = 262) to investigate sex-specific alterations in infant blood DNA methylation at birth (cord blood or neonatal blood spots). Prenatal exposure to several phthalates was suggestive of association with altered DNA methylation at 4 loci in males (all related to ΣDEHP) and 4 loci in females (1 related to ΣDiNP; 2 related to BBzP; and 1 related to MCPP) at a cutoff of q < 0.2. Additionally, a subset of dyads (n = 79) was used to interrogate the relationships between two compounds increasingly used as substitutions for common phthalates (ΣDINCH and ΣDEHTP) and cord blood DNA methylation. ΣDINCH, but not ΣDEHTP, was suggestive of association with DNA methylation (q < 0.2). Together, these results demonstrate that prenatal exposure to both classically used phthalate metabolites and their newer alternatives is associated with sex-specific infant DNA methylation. Research and regulatory actions regarding this chemical class should consider the developmental health effects of these compounds and aim to avoid regrettable substitution scenarios in the present and future.
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spelling pubmed-90100322022-04-15 Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth Petroff, Rebekah L. Padmanabhan, Vasantha Dolinoy, Dana C. Watkins, Deborah J. Ciarelli, Joseph Haggerty, Diana Ruden, Douglas M. Goodrich, Jaclyn M. Front Genet Genetics Phthalates are a diverse group of chemicals used in consumer products. Because they are so widespread, exposure to these compounds is nearly unavoidable. Recently, growing scientific consensus has suggested that phthalates produce health effects in developing infants and children. These effects may be mediated through mechanisms related to the epigenome, the constellation of mitotically heritable chemical marks and small compounds that guide transcription and translation. The present study examined the relationship between prenatal, first-trimester exposure of seven phthalates and epigenetics in two pregnancy cohorts (n = 262) to investigate sex-specific alterations in infant blood DNA methylation at birth (cord blood or neonatal blood spots). Prenatal exposure to several phthalates was suggestive of association with altered DNA methylation at 4 loci in males (all related to ΣDEHP) and 4 loci in females (1 related to ΣDiNP; 2 related to BBzP; and 1 related to MCPP) at a cutoff of q < 0.2. Additionally, a subset of dyads (n = 79) was used to interrogate the relationships between two compounds increasingly used as substitutions for common phthalates (ΣDINCH and ΣDEHTP) and cord blood DNA methylation. ΣDINCH, but not ΣDEHTP, was suggestive of association with DNA methylation (q < 0.2). Together, these results demonstrate that prenatal exposure to both classically used phthalate metabolites and their newer alternatives is associated with sex-specific infant DNA methylation. Research and regulatory actions regarding this chemical class should consider the developmental health effects of these compounds and aim to avoid regrettable substitution scenarios in the present and future. Frontiers Media S.A. 2022-03-31 /pmc/articles/PMC9010032/ /pubmed/35432478 http://dx.doi.org/10.3389/fgene.2022.793278 Text en Copyright © 2022 Petroff, Padmanabhan, Dolinoy, Watkins, Ciarelli, Haggerty, Ruden and Goodrich. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Petroff, Rebekah L.
Padmanabhan, Vasantha
Dolinoy, Dana C.
Watkins, Deborah J.
Ciarelli, Joseph
Haggerty, Diana
Ruden, Douglas M.
Goodrich, Jaclyn M.
Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth
title Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth
title_full Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth
title_fullStr Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth
title_full_unstemmed Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth
title_short Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth
title_sort prenatal exposures to common phthalates and prevalent phthalate alternatives and infant dna methylation at birth
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010032/
https://www.ncbi.nlm.nih.gov/pubmed/35432478
http://dx.doi.org/10.3389/fgene.2022.793278
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