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Heterozygous deletion of Cdc42bpb does not alter ethanol behaviors in mice.
The gene Cdc42bpb encodes a kinase with an important role in cell migration and neurodevelopment. Recent evidence suggests this gene also has an important function in the genomic response to alcohol in the brain. We tested mice with a heterozygous deletion of Cdc42bpb in a battery of three alcohol-r...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Caltech Library
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010111/ https://www.ncbi.nlm.nih.gov/pubmed/35622514 http://dx.doi.org/10.17912/micropub.biology.000537 |
| Sumario: | The gene Cdc42bpb encodes a kinase with an important role in cell migration and neurodevelopment. Recent evidence suggests this gene also has an important function in the genomic response to alcohol in the brain. We tested mice with a heterozygous deletion of Cdc42bpb in a battery of three alcohol-related behavioral tests: loss of righting reflex, light-dark box, and two-bottle choice drinking. Cdc42bpb +/- mice showed no significant differences from wild type littermates in the primary output measure of any of the three tests. Cdc42bpb +/- mice did show a mild hyperactivity in the light-dark box, as well as some urogenital deformities. |
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