Heterozygous deletion of Cdc42bpb does not alter ethanol behaviors in mice.

The gene Cdc42bpb encodes a kinase with an important role in cell migration and neurodevelopment. Recent evidence suggests this gene also has an important function in the genomic response to alcohol in the brain. We tested mice with a heterozygous deletion of Cdc42bpb in a battery of three alcohol-r...

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Autores principales: Foreman, Taylor N, Limaye, Ayanna T, Bogenpohl, James W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010111/
https://www.ncbi.nlm.nih.gov/pubmed/35622514
http://dx.doi.org/10.17912/micropub.biology.000537
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author Foreman, Taylor N
Limaye, Ayanna T
Bogenpohl, James W
author_facet Foreman, Taylor N
Limaye, Ayanna T
Bogenpohl, James W
author_sort Foreman, Taylor N
collection PubMed
description The gene Cdc42bpb encodes a kinase with an important role in cell migration and neurodevelopment. Recent evidence suggests this gene also has an important function in the genomic response to alcohol in the brain. We tested mice with a heterozygous deletion of Cdc42bpb in a battery of three alcohol-related behavioral tests: loss of righting reflex, light-dark box, and two-bottle choice drinking. Cdc42bpb +/- mice showed no significant differences from wild type littermates in the primary output measure of any of the three tests. Cdc42bpb +/- mice did show a mild hyperactivity in the light-dark box, as well as some urogenital deformities.
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spelling pubmed-90101112022-04-15 Heterozygous deletion of Cdc42bpb does not alter ethanol behaviors in mice. Foreman, Taylor N Limaye, Ayanna T Bogenpohl, James W MicroPubl Biol New Finding The gene Cdc42bpb encodes a kinase with an important role in cell migration and neurodevelopment. Recent evidence suggests this gene also has an important function in the genomic response to alcohol in the brain. We tested mice with a heterozygous deletion of Cdc42bpb in a battery of three alcohol-related behavioral tests: loss of righting reflex, light-dark box, and two-bottle choice drinking. Cdc42bpb +/- mice showed no significant differences from wild type littermates in the primary output measure of any of the three tests. Cdc42bpb +/- mice did show a mild hyperactivity in the light-dark box, as well as some urogenital deformities. Caltech Library 2022-03-17 /pmc/articles/PMC9010111/ /pubmed/35622514 http://dx.doi.org/10.17912/micropub.biology.000537 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Foreman, Taylor N
Limaye, Ayanna T
Bogenpohl, James W
Heterozygous deletion of Cdc42bpb does not alter ethanol behaviors in mice.
title Heterozygous deletion of Cdc42bpb does not alter ethanol behaviors in mice.
title_full Heterozygous deletion of Cdc42bpb does not alter ethanol behaviors in mice.
title_fullStr Heterozygous deletion of Cdc42bpb does not alter ethanol behaviors in mice.
title_full_unstemmed Heterozygous deletion of Cdc42bpb does not alter ethanol behaviors in mice.
title_short Heterozygous deletion of Cdc42bpb does not alter ethanol behaviors in mice.
title_sort heterozygous deletion of cdc42bpb does not alter ethanol behaviors in mice.
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010111/
https://www.ncbi.nlm.nih.gov/pubmed/35622514
http://dx.doi.org/10.17912/micropub.biology.000537
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