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The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer
BACKGROUND: Elevated platelet volume is the risk factor for the development and poor overall survival of colorectal cancer (CRC) patients. Both microsatellite status and platelet glycoprotein Ibα (GPIbα) are related to platelet volume in CRC patients. This study aimed to investigate platelet GPIbα e...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010183/ https://www.ncbi.nlm.nih.gov/pubmed/35432525 http://dx.doi.org/10.1155/2022/9012063 |
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author | Liu, Zeng-yao Jia, Qing-chun Wang, Wen Liu, Yu-xi Wang, Rui-tao Li, Jia-yu |
author_facet | Liu, Zeng-yao Jia, Qing-chun Wang, Wen Liu, Yu-xi Wang, Rui-tao Li, Jia-yu |
author_sort | Liu, Zeng-yao |
collection | PubMed |
description | BACKGROUND: Elevated platelet volume is the risk factor for the development and poor overall survival of colorectal cancer (CRC) patients. Both microsatellite status and platelet glycoprotein Ibα (GPIbα) are related to platelet volume in CRC patients. This study aimed to investigate platelet GPIbα ectodomain (termed glycocalicin) levels among CRC patients and the association between the glycocalicin levels and microsatellite status in CRC. METHODS: The clinical and laboratory data of 430 CRC patients between January 2018 and December 2018 in Harbin Medical University Cancer Hospital were collected. The microsatellite status was determined with a polymerase chain reaction. The participants were separated into high microsatellite instability (MSI-H) and microsatellite stable (MSS) groups according to microsatellite status. The glycocalicin levels were measured with an enzyme-linked immunosorbent assay, and the cut-off point was determined with the receiver-operating characteristics curve. The clinical and pathological characteristics were collected via electronic medical records. Logistic regression was used to explore the association between glycocalicin and microsatellite status. RESULTS: Among the 430 CRC patients enrolled, 64 patients (14.9%) were identified as MSI-H and others as MSS CRC. Glycocalicin levels were significantly reduced in patients with MSI-H than those with MSS. After controlling for potential confounders, logistic regression analysis revealed that glycocalicin levels were independently associated with MSI-H CRC. CONCLUSIONS: Reduced glycocalicin levels are associated with the MSI-H subtype of CRC. Further research is needed to elucidate the mechanisms of the association between glycocalicin and MSI-H in CRC patients. |
format | Online Article Text |
id | pubmed-9010183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-90101832022-04-15 The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer Liu, Zeng-yao Jia, Qing-chun Wang, Wen Liu, Yu-xi Wang, Rui-tao Li, Jia-yu Gastroenterol Res Pract Research Article BACKGROUND: Elevated platelet volume is the risk factor for the development and poor overall survival of colorectal cancer (CRC) patients. Both microsatellite status and platelet glycoprotein Ibα (GPIbα) are related to platelet volume in CRC patients. This study aimed to investigate platelet GPIbα ectodomain (termed glycocalicin) levels among CRC patients and the association between the glycocalicin levels and microsatellite status in CRC. METHODS: The clinical and laboratory data of 430 CRC patients between January 2018 and December 2018 in Harbin Medical University Cancer Hospital were collected. The microsatellite status was determined with a polymerase chain reaction. The participants were separated into high microsatellite instability (MSI-H) and microsatellite stable (MSS) groups according to microsatellite status. The glycocalicin levels were measured with an enzyme-linked immunosorbent assay, and the cut-off point was determined with the receiver-operating characteristics curve. The clinical and pathological characteristics were collected via electronic medical records. Logistic regression was used to explore the association between glycocalicin and microsatellite status. RESULTS: Among the 430 CRC patients enrolled, 64 patients (14.9%) were identified as MSI-H and others as MSS CRC. Glycocalicin levels were significantly reduced in patients with MSI-H than those with MSS. After controlling for potential confounders, logistic regression analysis revealed that glycocalicin levels were independently associated with MSI-H CRC. CONCLUSIONS: Reduced glycocalicin levels are associated with the MSI-H subtype of CRC. Further research is needed to elucidate the mechanisms of the association between glycocalicin and MSI-H in CRC patients. Hindawi 2022-04-07 /pmc/articles/PMC9010183/ /pubmed/35432525 http://dx.doi.org/10.1155/2022/9012063 Text en Copyright © 2022 Zeng-yao Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Zeng-yao Jia, Qing-chun Wang, Wen Liu, Yu-xi Wang, Rui-tao Li, Jia-yu The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer |
title | The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer |
title_full | The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer |
title_fullStr | The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer |
title_full_unstemmed | The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer |
title_short | The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer |
title_sort | association between platelet glycocalicin and high microsatellite instability in colorectal cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010183/ https://www.ncbi.nlm.nih.gov/pubmed/35432525 http://dx.doi.org/10.1155/2022/9012063 |
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