Cargando…

Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults

Aging is associated with poor sleep quality and greater chronic pain prevalence, with age-related changes in brain function as potential underlying mechanisms. Objective. The following cross-sectional study aimed to determine whether self-reported chronic musculoskeletal pain in community-dwelling o...

Descripción completa

Detalles Bibliográficos
Autores principales: Montesino-Goicolea, Soamy, Valdes-Hernandez, Pedro A., Cruz-Almeida, Yenisel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010216/
https://www.ncbi.nlm.nih.gov/pubmed/35432664
http://dx.doi.org/10.1155/2022/4347759
_version_ 1784687437121847296
author Montesino-Goicolea, Soamy
Valdes-Hernandez, Pedro A.
Cruz-Almeida, Yenisel
author_facet Montesino-Goicolea, Soamy
Valdes-Hernandez, Pedro A.
Cruz-Almeida, Yenisel
author_sort Montesino-Goicolea, Soamy
collection PubMed
description Aging is associated with poor sleep quality and greater chronic pain prevalence, with age-related changes in brain function as potential underlying mechanisms. Objective. The following cross-sectional study aimed to determine whether self-reported chronic musculoskeletal pain in community-dwelling older adults moderates the association between sleep quality and resting state functional brain connectivity (rsFC). Methods. Community-dwelling older individuals (mean age = 73.29 years) part of the NEPAL study who completed the Pittsburg Sleep Quality Index (PSQI) and a rsFC scan were included (n = 48) in the present investigation. To that end, we tested the effect of chronic pain-by-PSQI interaction on rsFC among atlas-based brain regions-of-interest, controlling for age and sex. Results and Discussion. A significant network connecting the bilateral putamen and left caudate with bilateral precentral gyrus, postcentral gyrus, and juxtapositional lobule cortex, survived global multiple comparisons (FDR; q < 0.05) and threshold-free network-based-statistics. Greater PSQI scores were significantly associated with greater dorsostriatal-sensorimotor rsFC in the no-pain group, suggesting that a state of somatomotor hyperarousal may be associated with poorer sleep quality in this group. However, in the pain group, greater PSQI scores were associated with less dorsostriatal-sensorimotor rsFC, possibly due to a shift of striatal functions toward regulation sensorimotor aspects of the pain experience, and/or aberrant cortico-striatal loops in the presence of chronic pain. This preliminary investigation advances knowledge about the neurobiology underlying the associations between chronic pain and sleep in community-dwelling older adults that may contribute to the development of effective therapies to decrease disability in geriatric populations.
format Online
Article
Text
id pubmed-9010216
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-90102162022-04-15 Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults Montesino-Goicolea, Soamy Valdes-Hernandez, Pedro A. Cruz-Almeida, Yenisel Pain Res Manag Research Article Aging is associated with poor sleep quality and greater chronic pain prevalence, with age-related changes in brain function as potential underlying mechanisms. Objective. The following cross-sectional study aimed to determine whether self-reported chronic musculoskeletal pain in community-dwelling older adults moderates the association between sleep quality and resting state functional brain connectivity (rsFC). Methods. Community-dwelling older individuals (mean age = 73.29 years) part of the NEPAL study who completed the Pittsburg Sleep Quality Index (PSQI) and a rsFC scan were included (n = 48) in the present investigation. To that end, we tested the effect of chronic pain-by-PSQI interaction on rsFC among atlas-based brain regions-of-interest, controlling for age and sex. Results and Discussion. A significant network connecting the bilateral putamen and left caudate with bilateral precentral gyrus, postcentral gyrus, and juxtapositional lobule cortex, survived global multiple comparisons (FDR; q < 0.05) and threshold-free network-based-statistics. Greater PSQI scores were significantly associated with greater dorsostriatal-sensorimotor rsFC in the no-pain group, suggesting that a state of somatomotor hyperarousal may be associated with poorer sleep quality in this group. However, in the pain group, greater PSQI scores were associated with less dorsostriatal-sensorimotor rsFC, possibly due to a shift of striatal functions toward regulation sensorimotor aspects of the pain experience, and/or aberrant cortico-striatal loops in the presence of chronic pain. This preliminary investigation advances knowledge about the neurobiology underlying the associations between chronic pain and sleep in community-dwelling older adults that may contribute to the development of effective therapies to decrease disability in geriatric populations. Hindawi 2022-04-07 /pmc/articles/PMC9010216/ /pubmed/35432664 http://dx.doi.org/10.1155/2022/4347759 Text en Copyright © 2022 Soamy Montesino-Goicolea et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Montesino-Goicolea, Soamy
Valdes-Hernandez, Pedro A.
Cruz-Almeida, Yenisel
Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults
title Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults
title_full Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults
title_fullStr Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults
title_full_unstemmed Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults
title_short Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults
title_sort chronic musculoskeletal pain moderates the association between sleep quality and dorsostriatal-sensorimotor resting state functional connectivity in community-dwelling older adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010216/
https://www.ncbi.nlm.nih.gov/pubmed/35432664
http://dx.doi.org/10.1155/2022/4347759
work_keys_str_mv AT montesinogoicoleasoamy chronicmusculoskeletalpainmoderatestheassociationbetweensleepqualityanddorsostriatalsensorimotorrestingstatefunctionalconnectivityincommunitydwellingolderadults
AT valdeshernandezpedroa chronicmusculoskeletalpainmoderatestheassociationbetweensleepqualityanddorsostriatalsensorimotorrestingstatefunctionalconnectivityincommunitydwellingolderadults
AT cruzalmeidayenisel chronicmusculoskeletalpainmoderatestheassociationbetweensleepqualityanddorsostriatalsensorimotorrestingstatefunctionalconnectivityincommunitydwellingolderadults