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Peppermint oil effects on the gut microbiome in children with functional abdominal pain

Peppermint oil (PMO) is effective in the treatment of functional abdominal pain disorders, but its mechanism of action is unclear. Evidence suggests PMO has microbicidal activity. We investigated the effect of three different doses of PMO on gut microbiome composition. Thirty children (7–12 years of...

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Autores principales: Thapa, Santosh, Luna, Ruth Ann, Chumpitazi, Bruno P., Oezguen, Numan, Abdel‐Rahman, Susan M., Garg, Uttam, Musaad, Salma, Versalovic, James, Kearns, Gregory L., Shulman, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010253/
https://www.ncbi.nlm.nih.gov/pubmed/35048535
http://dx.doi.org/10.1111/cts.13224
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author Thapa, Santosh
Luna, Ruth Ann
Chumpitazi, Bruno P.
Oezguen, Numan
Abdel‐Rahman, Susan M.
Garg, Uttam
Musaad, Salma
Versalovic, James
Kearns, Gregory L.
Shulman, Robert J.
author_facet Thapa, Santosh
Luna, Ruth Ann
Chumpitazi, Bruno P.
Oezguen, Numan
Abdel‐Rahman, Susan M.
Garg, Uttam
Musaad, Salma
Versalovic, James
Kearns, Gregory L.
Shulman, Robert J.
author_sort Thapa, Santosh
collection PubMed
description Peppermint oil (PMO) is effective in the treatment of functional abdominal pain disorders, but its mechanism of action is unclear. Evidence suggests PMO has microbicidal activity. We investigated the effect of three different doses of PMO on gut microbiome composition. Thirty children (7–12 years of age) with functional abdominal pain provided a baseline stool sample prior to randomization to 180, 360, or 540 mg of enteric coated PMO (10 participants per dose). They took their respective dose of PMO (180 mg once, 180 mg twice, or 180 mg thrice daily) for 1 week, after which the stool collection was repeated. Baseline and post‐PMO stools were analyzed for microbiome composition. There was no difference in alpha diversity of the gut microbiome between the baseline and post‐PMO treatment. Principal coordinate analysis revealed no significant difference in overall bacterial composition between baseline and post‐PMO samples, as well as between the PMO dose groups. However, the very low abundant Collinsella genus and three operational taxonomic units (one belonging to Collinsella) were significantly different in samples before and after PMO treatment. The Firmicutes/Bacteroidetes ratio was lower in children who received 540 mg of PMO compared to the 180 mg and 360 mg dose groups (p = 0.04). Network analysis revealed separation between pre‐ and post‐PMO fecal samples with the genus Collinsella driving the post‐PMO clusters. PMO administration appeared to impact only low abundance bacteria. The 540 mg PMO dose differentially impacted the Firmicutes/Bacteroidetes ratio. A higher dose and/or longer duration of treatment might yield different results.
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spelling pubmed-90102532022-04-18 Peppermint oil effects on the gut microbiome in children with functional abdominal pain Thapa, Santosh Luna, Ruth Ann Chumpitazi, Bruno P. Oezguen, Numan Abdel‐Rahman, Susan M. Garg, Uttam Musaad, Salma Versalovic, James Kearns, Gregory L. Shulman, Robert J. Clin Transl Sci Research Peppermint oil (PMO) is effective in the treatment of functional abdominal pain disorders, but its mechanism of action is unclear. Evidence suggests PMO has microbicidal activity. We investigated the effect of three different doses of PMO on gut microbiome composition. Thirty children (7–12 years of age) with functional abdominal pain provided a baseline stool sample prior to randomization to 180, 360, or 540 mg of enteric coated PMO (10 participants per dose). They took their respective dose of PMO (180 mg once, 180 mg twice, or 180 mg thrice daily) for 1 week, after which the stool collection was repeated. Baseline and post‐PMO stools were analyzed for microbiome composition. There was no difference in alpha diversity of the gut microbiome between the baseline and post‐PMO treatment. Principal coordinate analysis revealed no significant difference in overall bacterial composition between baseline and post‐PMO samples, as well as between the PMO dose groups. However, the very low abundant Collinsella genus and three operational taxonomic units (one belonging to Collinsella) were significantly different in samples before and after PMO treatment. The Firmicutes/Bacteroidetes ratio was lower in children who received 540 mg of PMO compared to the 180 mg and 360 mg dose groups (p = 0.04). Network analysis revealed separation between pre‐ and post‐PMO fecal samples with the genus Collinsella driving the post‐PMO clusters. PMO administration appeared to impact only low abundance bacteria. The 540 mg PMO dose differentially impacted the Firmicutes/Bacteroidetes ratio. A higher dose and/or longer duration of treatment might yield different results. John Wiley and Sons Inc. 2022-01-20 2022-04 /pmc/articles/PMC9010253/ /pubmed/35048535 http://dx.doi.org/10.1111/cts.13224 Text en © 2021 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research
Thapa, Santosh
Luna, Ruth Ann
Chumpitazi, Bruno P.
Oezguen, Numan
Abdel‐Rahman, Susan M.
Garg, Uttam
Musaad, Salma
Versalovic, James
Kearns, Gregory L.
Shulman, Robert J.
Peppermint oil effects on the gut microbiome in children with functional abdominal pain
title Peppermint oil effects on the gut microbiome in children with functional abdominal pain
title_full Peppermint oil effects on the gut microbiome in children with functional abdominal pain
title_fullStr Peppermint oil effects on the gut microbiome in children with functional abdominal pain
title_full_unstemmed Peppermint oil effects on the gut microbiome in children with functional abdominal pain
title_short Peppermint oil effects on the gut microbiome in children with functional abdominal pain
title_sort peppermint oil effects on the gut microbiome in children with functional abdominal pain
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010253/
https://www.ncbi.nlm.nih.gov/pubmed/35048535
http://dx.doi.org/10.1111/cts.13224
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