Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS‐1211, a tissue‐nonspecific alkaline phosphatase inhibitor

Tissue‐nonspecific alkaline phosphatase (TNAP) hydrolyzes and inactivates inorganic pyrophosphate (PPi), a potent inhibitor of calcification; therefore, TNAP inhibition is a potential target to treat ectopic calcification. These two first‐in‐human studies evaluated safety, tolerability, pharmacokine...

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Detalles Bibliográficos
Autores principales: Maruyama, Sonomi, Visser, Hester, Ito, Takashi, Limsakun, Tharin, Zahir, Hamim, Ford, Daniel, Tao, Ben, Zamora, Cynthia A., Stark, Jeffrey G., Chou, Hubert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010257/
https://www.ncbi.nlm.nih.gov/pubmed/35021269
http://dx.doi.org/10.1111/cts.13214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010257/
https://www.ncbi.nlm.nih.gov/pubmed/35021269
http://dx.doi.org/10.1111/cts.13214

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