Cargando…

Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair

The tumor stroma of pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant and heterogeneous population of cancer-associated fibroblasts (CAFs), which are critically involved in chemoresistance. However, the underlying mechanism of CAFs in chemoresistance is unclear. Here, we show t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xiang, Zheng, Shangyou, Hu, Chonghui, Li, Guolin, Lin, Hongcao, Xia, Renpeng, Ye, Yuancheng, He, Rihua, Li, Zhihua, Lin, Qing, Chen, Rufu, Zhou, Quanbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010302/ https://www.ncbi.nlm.nih.gov/pubmed/35264742 http://dx.doi.org/10.1038/s41388-022-02253-6

Ejemplares similares

circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-κB signaling pathway
por: Zheng, Shangyou, et al.
Publicado: (2022)

circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis
por: Hu, Chonghui, et al.
Publicado: (2022)

A novel gene signature for prognosis prediction and chemotherapy response in patients with pancreatic cancer
por: Lin, Hongcao, et al.
Publicado: (2021)

HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1
por: Xia, Renpeng, et al.
Publicado: (2023)

Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer
por: Zheng, Shangyou, et al.
Publicado: (2023)

Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer
por: Wei, Lusheng, et al.
Publicado: (2018)

Correction: Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer
por: Wei, Lusheng, et al.
Publicado: (2021)

Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma
por: Ye, Huilin, et al.
Publicado: (2018)

FEZF1-AS1/miR-107/ZNF312B axis facilitates progression and Warburg effect in pancreatic ductal adenocarcinoma
por: Ye, Huilin, et al.
Publicado: (2018)

Endogenous miRNA Sponge LincRNA-ROR promotes proliferation, invasion and stem cell-like phenotype of pancreatic cancer cells
por: Fu, Zhiqiang, et al.
Publicado: (2017)

Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation
por: Wei, Lusheng, et al.
Publicado: (2021)

lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer
por: Ren, Xiaofan, et al.
Publicado: (2020)

Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer: a multicenter randomized controlled trial
por: Lin, Qing, et al.
Publicado: (2022)

Comprehensive analysis reveals CTHRC1, SERPINE1, VCAN and UPK1B as the novel prognostic markers in gastric cancer
por: Zhu, Zhipeng, et al.
Publicado: (2020)

Correction: lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer
por: Ren, Xiaofan, et al.
Publicado: (2022)

Upk3b Is Dispensable for Development and Integrity of Urothelium and Mesothelium
por: Rudat, Carsten, et al.
Publicado: (2014)

Expression profile of long non-coding RNAs in pancreatic cancer and their clinical significance as biomarkers
por: Wang, Yingxue, et al.
Publicado: (2015)

LRRN4 and UPK3B Are Markers of Primary Mesothelial Cells
por: Kanamori-Katayama, Mutsumi, et al.
Publicado: (2011)

Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor
por: Zhou, Yu, et al.
Publicado: (2021)

Comparison of RNAscope and immunohistochemistry for evaluation of the UPK2 status in urothelial carcinoma tissues
por: Lu, Jiangli, et al.
Publicado: (2022)

LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation
por: Cheng, Di, et al.
Publicado: (2018)

High Expression of UPK3A Promotes the Progression of Gastric Cancer Cells by Inactivating p53 Pathway
por: Xu, Deliang, et al.
Publicado: (2022)

Deciphering the functional mechanism of zinc ions of PARP1 binding with single strand breaks and double strand breaks
por: Sun, Shuya, et al.
Publicado: (2022)

High expression of AFAP1-AS1 is associated with poor survival and short-term recurrence in pancreatic ductal adenocarcinoma
por: Ye, Yibiao, et al.
Publicado: (2015)

Genetic Variants in Double-Strand Break Repair Pathway Genes to Predict Platinum-Based Chemotherapy Prognosis in Patients With Lung Cancer
por: Liu, Jun-Yan, et al.
Publicado: (2022)

Long noncoding RNA UPK1A-AS1 indicates poor prognosis of hepatocellular carcinoma and promotes cell proliferation through interaction with EZH2
por: Zhang, Dong-Yan, et al.
Publicado: (2020)

The Prognostic Value of LncRNA SLNCR1 in Cancers: A Meta-Analysis
por: Cong, Lele, et al.
Publicado: (2021)

The Tetraspanin-Associated Uroplakins Family (UPK2/3) Is Evolutionarily Related to PTPRQ, a Phosphotyrosine Phosphatase Receptor
por: Chicote, Javier U., et al.
Publicado: (2017)

State of the Science for Kidney Disorders in Phelan-McDermid Syndrome: UPK3A, FBLN1, WNT7B, and CELSR1 as Candidate Genes
por: McCoy, Megan D., et al.
Publicado: (2022)

APE1 senses DNA single-strand breaks for repair and signaling
por: Lin, Yunfeng, et al.
Publicado: (2020)

Metabolic Phenotypes in Pancreatic Cancer
por: Yu, Min, et al.
Publicado: (2015)

The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer
por: Li, Zhihua, et al.
Publicado: (2015)

Oxidative DNA double strand breaks and autophagy in the antitumor effect of sterically hindered platinum(II) complexes in NSCLCs
por: Chen, Feihong, et al.
Publicado: (2017)

Correction: The Tetraspanin-Associated Uroplakins Family (UPK2/3) Is Evolutionarily Related to PTPRQ, a Phosphotyrosine Phosphatase Receptor
por: Chicote, Javier U., et al.
Publicado: (2017)

Restoration of UPK1A-AS1 Expression Suppresses Cell Proliferation, Migration, and Invasion in Esophageal Squamous Cell Carcinoma Cells Partially by Sponging microRNA-1248
por: Du, Fang, et al.
Publicado: (2020)

Tumor-neuroglia interaction promotes pancreatic cancer metastasis
por: Su, Dan, et al.
Publicado: (2020)

Harnessing DNA Double-Strand Break Repair for Cancer Treatment
por: Trenner, Anika, et al.
Publicado: (2019)

Meiotic Genes and DNA Double Strand Break Repair in Cancer
por: Lingg, Lea, et al.
Publicado: (2022)

Role of Elg1 protein in double strand break repair
por: Ogiwara, Hideaki, et al.
Publicado: (2007)

Radical nerve dissection for the carcinoma of head of pancreas: report of 30 cases
por: Lin, Qing, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4jv581h7of91plb68u3qthd7sh