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Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation
Coronaviruses are the etiologic agents of several diseases. Coronaviruses of critical medical importance are characterized by highly inflammatory pathophysiology, involving severe pulmonary impairment and infection of multiple cell types within the body. Here, we discuss the interplay between corona...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010404/ https://www.ncbi.nlm.nih.gov/pubmed/35433503 http://dx.doi.org/10.3389/fcimb.2022.845368 |
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author | Silva, Rafael Cardoso Maciel Costa Ribeiro, Jhones Sousa da Silva, Gustavo Peixoto Duarte da Costa, Luciana Jesus Travassos, Leonardo Holanda |
author_facet | Silva, Rafael Cardoso Maciel Costa Ribeiro, Jhones Sousa da Silva, Gustavo Peixoto Duarte da Costa, Luciana Jesus Travassos, Leonardo Holanda |
author_sort | Silva, Rafael Cardoso Maciel Costa |
collection | PubMed |
description | Coronaviruses are the etiologic agents of several diseases. Coronaviruses of critical medical importance are characterized by highly inflammatory pathophysiology, involving severe pulmonary impairment and infection of multiple cell types within the body. Here, we discuss the interplay between coronaviruses and autophagy regarding virus life cycle, cell resistance, and inflammation, highlighting distinct mechanisms by which autophagy restrains inflammatory responses, especially those involved in coronavirus pathogenesis. We also address different autophagy modulators available and the rationale for drug repurposing as an attractive adjunctive therapy. We focused on pharmaceuticals being tested in clinical trials with distinct mechanisms but with autophagy as a common target. These autophagy modulators act in cell resistance to virus infection and immunomodulation, providing a double-strike to prevent or treat severe disease development and death from coronaviruses diseases. |
format | Online Article Text |
id | pubmed-9010404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90104042022-04-16 Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation Silva, Rafael Cardoso Maciel Costa Ribeiro, Jhones Sousa da Silva, Gustavo Peixoto Duarte da Costa, Luciana Jesus Travassos, Leonardo Holanda Front Cell Infect Microbiol Cellular and Infection Microbiology Coronaviruses are the etiologic agents of several diseases. Coronaviruses of critical medical importance are characterized by highly inflammatory pathophysiology, involving severe pulmonary impairment and infection of multiple cell types within the body. Here, we discuss the interplay between coronaviruses and autophagy regarding virus life cycle, cell resistance, and inflammation, highlighting distinct mechanisms by which autophagy restrains inflammatory responses, especially those involved in coronavirus pathogenesis. We also address different autophagy modulators available and the rationale for drug repurposing as an attractive adjunctive therapy. We focused on pharmaceuticals being tested in clinical trials with distinct mechanisms but with autophagy as a common target. These autophagy modulators act in cell resistance to virus infection and immunomodulation, providing a double-strike to prevent or treat severe disease development and death from coronaviruses diseases. Frontiers Media S.A. 2022-03-24 /pmc/articles/PMC9010404/ /pubmed/35433503 http://dx.doi.org/10.3389/fcimb.2022.845368 Text en Copyright © 2022 Silva, Ribeiro, da Silva, da Costa and Travassos https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Silva, Rafael Cardoso Maciel Costa Ribeiro, Jhones Sousa da Silva, Gustavo Peixoto Duarte da Costa, Luciana Jesus Travassos, Leonardo Holanda Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation |
title | Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation |
title_full | Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation |
title_fullStr | Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation |
title_full_unstemmed | Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation |
title_short | Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation |
title_sort | autophagy modulators in coronavirus diseases: a double strike in viral burden and inflammation |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010404/ https://www.ncbi.nlm.nih.gov/pubmed/35433503 http://dx.doi.org/10.3389/fcimb.2022.845368 |
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