PINK1-mediated Drp1(S616) phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission

Dynamic change of mitochondrial morphology and distribution along neuronal branches are essential for neural circuitry formation and synaptic efficacy. However, the underlying mechanism remains elusive. We show here that Pink1 knockout (KO) mice display defective dendritic spine maturation, reduced...

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Detalles Bibliográficos
Autores principales: Gao, Qingtao, Tian, Runyi, Han, Hailong, Slone, Jesse, Wang, Caifang, Ke, Xiao, Zhang, Tongmei, Li, Xiangyu, He, Yuhong, Liao, Panlin, Wang, Fang, Chen, Ye, Fu, Shiqing, Zhang, Kexuan, Zeng, Fangfang, Yang, Yingxuan, Li, Zhuo, Tan, Jieqiong, Li, Jiada, Lu, Youming, Huang, Taosheng, Hu, Zhonghua, Zhang, Zhuohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010405/
https://www.ncbi.nlm.nih.gov/pubmed/35422062
http://dx.doi.org/10.1038/s41392-022-00933-z

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